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Azelnidipine

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Catalog No. T0121Cas No. 123524-52-7
Alias UR-12592, CS 905

Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.

Azelnidipine
Other Forms of Azelnidipine:

Azelnidipine

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Purity: 99.78%
Catalog No. T0121Alias UR-12592, CS 905Cas No. 123524-52-7
Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$30In StockIn Stock
5 mg$44In StockIn Stock
10 mg$62In StockIn Stock
25 mg$111In StockIn Stock
50 mg$179In StockIn Stock
100 mg$289In StockIn Stock
200 mg$428In StockIn Stock
1 mL x 10 mM (in DMSO)$57In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.78%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.
In vivo
Studies indicate that Azelnidipine, as a new-generation calcium channel blocker, can treat hypertension regardless of the patient's risk for ischemic heart disease. This novel, long-acting calcium channel blocker exhibits unique pharmacological properties, such as a slower heart rate and high affinity for vascular tissue, distinguishing it from other calcium channel blockers. Additionally, the high lipophilicity of Azelnidipine allows it to remain active in the vascular wall even after being cleared from the bloodstream.
SynonymsUR-12592, CS 905
Chemical Properties
Molecular Weight582.65
FormulaC33H34N4O6
Cas No.123524-52-7
SmilesO=C(C1=C(N)NC(C)=C(C(OC(C)C)=O)C1C2=CC([N+]([O-])=O)=CC=C2)OC3CN(C3)C(C4=CC=CC=C4)C5=CC=CC=C5
Relative Density.1.33 g/cm3
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 7 mg/mL (12.01 mM), Sonication is recommended.
DMSO: 108 mg/mL (185.36 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.87 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.7163 mL8.5815 mL17.1630 mL85.8148 mL
5 mM0.3433 mL1.7163 mL3.4326 mL17.1630 mL
10 mM0.1716 mL0.8581 mL1.7163 mL8.5815 mL
DMSO
1mg5mg10mg50mg
20 mM0.0858 mL0.4291 mL0.8581 mL4.2907 mL
50 mM0.0343 mL0.1716 mL0.3433 mL1.7163 mL
100 mM0.0172 mL0.0858 mL0.1716 mL0.8581 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

UR12592UR 12592InhibitorinhibitCS-905CS905CalciumChannelCalcium ChannelCa2+ channelsCa channelsAzelnidipine
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