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Azelnidipine

🥰Excellent
Catalog No. T0121Cas No. 123524-52-7
Alias UR-12592, CS 905

Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.

Azelnidipine
Other Forms of Azelnidipine:

Azelnidipine

🥰Excellent
Purity: 99.78%
Catalog No. T0121Alias UR-12592, CS 905Cas No. 123524-52-7
Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$30In StockIn Stock
5 mg$44In StockIn Stock
10 mg$62In StockIn Stock
25 mg$111In StockIn Stock
50 mg$179In StockIn Stock
100 mg$289In StockIn Stock
200 mg$428In StockIn Stock
1 mL x 10 mM (in DMSO)$57In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.78%
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Product Introduction

Bioactivity
Description
Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.
In vivo
Studies indicate that Azelnidipine, as a new-generation calcium channel blocker, can treat hypertension regardless of the patient's risk for ischemic heart disease. This novel, long-acting calcium channel blocker exhibits unique pharmacological properties, such as a slower heart rate and high affinity for vascular tissue, distinguishing it from other calcium channel blockers. Additionally, the high lipophilicity of Azelnidipine allows it to remain active in the vascular wall even after being cleared from the bloodstream.
SynonymsUR-12592, CS 905
Chemical Properties
Molecular Weight582.65
FormulaC33H34N4O6
Cas No.123524-52-7
SmilesO=C(C1=C(N)NC(C)=C(C(OC(C)C)=O)C1C2=CC([N+]([O-])=O)=CC=C2)OC3CN(C3)C(C4=CC=CC=C4)C5=CC=CC=C5
Relative Density.1.33 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 7 mg/mL (12.01 mM), Sonication is recommended.
DMSO: 108 mg/mL (185.36 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.87 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.7163 mL8.5815 mL17.1630 mL85.8148 mL
5 mM0.3433 mL1.7163 mL3.4326 mL17.1630 mL
10 mM0.1716 mL0.8581 mL1.7163 mL8.5815 mL
DMSO
1mg5mg10mg50mg
20 mM0.0858 mL0.4291 mL0.8581 mL4.2907 mL
50 mM0.0343 mL0.1716 mL0.3433 mL1.7163 mL
100 mM0.0172 mL0.0858 mL0.1716 mL0.8581 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

UR12592UR 12592InhibitorinhibitCS-905CS905CalciumChannelCalcium ChannelCa2+ channelsCa channelsAzelnidipine
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