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123C4

Name: 123C4
Brand: TargetMol
SKU: TP1561
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1561 Copy Product Info

Purity: 98.94%

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123C4 is a selective, competitive receptor tyrosine kinase EPHA4 agonist with a Ki of 0.65 μM. 123C4 can be used in amyotrophic lateral sclerosis (ALS) research.

Cas No. 2034159-30-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$147	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$538	In Stock	In Stock
25 mg	$857	In Stock	In Stock
50 mg	$1,150	In Stock	In Stock
100 mg	$1,550	-	In Stock
1 mL x 10 mM (in DMSO)	$533	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.94%

Appearance:Solid

Color:Purple

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COA LCMS HNMR

Product Introduction

123C4 AI Summary

123C4 exhibits significant binding affinity to the EphA4 ligand binding domain (LBD). According to various assessments including isothermal titration calorimetry (ITC) and 2D-[13C-1H] HSQC NMR spectroscopy, it has a dissociation constant (Kd) of approximately 400.0-420.0 nM, indicating strong interaction with specific residues in the EphA4 LBD. Additionally, it has been observed to have an inhibition constant (Ki) of 640.0 nM, suggesting competitive inhibition of ligand binding. 123C4 displays high solubility up to 100000.0 nM and does not significantly bind to the EphA3 LBD. These findings imply that 123C4 may have potential bioactivity related to EphA4 receptor function and signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	123C4 is a selective, competitive receptor tyrosine kinase EPHA4 agonist with a Ki of 0.65 μM. 123C4 can be used in amyotrophic lateral sclerosis (ALS) research.
Targets & IC50	EphA4:0.65 μM (Ki)
In vitro	Methods: Neural progenitor cells were derived from fibroblasts obtained from ALS patients with different subtypes through rapid reprogramming. These cells were then differentiated. The two cell types were co-cultured to induce motor neuron (MN) death. 123C4 (100 μM) was added to the co-culture system and treated for 3 days, after which the number of surviving MNs was counted. Results: 123C4 effectively protected motor neurons from cell death induced by astrocytes from all tested ALS patients. [1]

Chemical Properties

Molecular Weight	807.34
Formula	C₄₃H₄₇ClN₈O₆
Cas No.	2034159-30-1
Smiles	COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1
Relative Density.	1.345 g/cm3 (Predicted)
Sequence	Deamino-Dab-Trp(5-OH)-Phe(4-Cl)-4Pal-Unk
Sequence Short	XWFXX

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (312.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2386 mL	6.1932 mL	12.3864 mL	61.9318 mL
5 mM	0.2477 mL	1.2386 mL	2.4773 mL	12.3864 mL
10 mM	0.1239 mL	0.6193 mL	1.2386 mL	6.1932 mL
20 mM	0.0619 mL	0.3097 mL	0.6193 mL	3.0966 mL
50 mM	0.0248 mL	0.1239 mL	0.2477 mL	1.2386 mL
100 mM	0.0124 mL	0.0619 mL	0.1239 mL	0.6193 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.