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Blarcamesine hydrochloride

Name: Blarcamesine hydrochloride
Brand: TargetMol
SKU: T4111
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4111Cas No. 195615-84-0

Alias AVex-73 hydrochloride, Anavex 2-73, AE-37 hydrochloride

Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).

Blarcamesine hydrochloride

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Purity: 99.9%

Catalog No. T4111Alias AVex-73 hydrochloride, Anavex 2-73, AE-37 hydrochlorideCas No. 195615-84-0

Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
2 mg	$40	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$106	In Stock	In Stock
25 mg	$218	In Stock	In Stock
50 mg	$378	In Stock	In Stock
100 mg	$619	In Stock	In Stock
200 mg	$877	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).
Targets&IC50	σ1 receptor:860 nM
In vivo	The pretreatment of Blarcamesine(1/3 mg/kg) dose-dependently reduces the scopolamine-induced alternation deficit. The pretreatment with Blarcamesine(>0.3 mg/kg) dose-dependently and significantly attenuates the impairments of step-through latency[1]. The Blarcamesine(1mg/kg) dose-dependently blocks the recognition memory deficit. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine(0.1/1mg/kg). Seven days after injections, Blarcamesineattenuates the decrease in Ser9 phosphorylation induced by the peptide (0.3/1mg/kg)[2].
Animal Research	Drugs (including Anavex 2-73) are solubilized in physiological saline at the concentration of 5?mg/mL.Male mice aged 7-9 weeks and weighing 32±2?g are used. Drugs (including Anavex 2-73) are brought up to each dose by dilution and injected in a volume of 100?μL/20?g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures.
Synonyms	AVex-73 hydrochloride, Anavex 2-73, AE-37 hydrochloride

Chemical Properties

Molecular Weight	317.85
Formula	C₁₉H₂₄ClNO
Cas No.	195615-84-0
Smiles	Cl.CN(C)CC1CCOC1(c1ccccc1)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (173.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1461 mL	15.7307 mL	31.4614 mL	157.3069 mL
5 mM	0.6292 mL	3.1461 mL	6.2923 mL	31.4614 mL
10 mM	0.3146 mL	1.5731 mL	3.1461 mL	15.7307 mL
20 mM	0.1573 mL	0.7865 mL	1.5731 mL	7.8653 mL
50 mM	0.0629 mL	0.3146 mL	0.6292 mL	3.1461 mL
100 mM	0.0315 mL	0.1573 mL	0.3146 mL	1.5731 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc