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3,4,5-Trihydroxycinnamic acid decyl ester

🥰Excellent
Catalog No. T39189Cas No. 1770778-45-4

3,4,5-Trihydroxycinnamic acid decyl ester, an effective inhibitor of lipid absorption and accumulation, exhibits anti-obesity properties and acts as a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM.

3,4,5-Trihydroxycinnamic acid decyl ester

3,4,5-Trihydroxycinnamic acid decyl ester

🥰Excellent
Purity: 98.28%
Catalog No. T39189Cas No. 1770778-45-4
3,4,5-Trihydroxycinnamic acid decyl ester, an effective inhibitor of lipid absorption and accumulation, exhibits anti-obesity properties and acts as a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$69-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.28%
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Product Introduction

Bioactivity
Description
3,4,5-Trihydroxycinnamic acid decyl ester, an effective inhibitor of lipid absorption and accumulation, exhibits anti-obesity properties and acts as a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM.
Targets&IC50
Pancreatic lipase:0.9 μM (EC50)
In vitro
3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) inhibits pancreatic lipase activity by approximately 92% in vitro[1]. This compound exhibits dose-dependent inhibition of pancreatic lipase between 0.1-40 μM, with an EC50 around 0.9 μM[1]. Additionally, it prevents lipid accumulation during 3T3-L1 cell differentiation, indicating potential in influencing lipid metabolism[1].
In vivo
3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) effectively suppresses the elevation of blood triglyceride (TG) levels in 6-week-old male ddY mice administered corn oil orally, with the compound showing a dose-dependent reduction in plasma TG levels at dosages of 30 mg/kg and 150 mg/kg[1].
Chemical Properties
Molecular Weight336.42
FormulaC19H28O5
Cas No.1770778-45-4
SmilesCCCCCCCCCCOC(=O)\C=C\c1cc(O)c(O)c(O)c1
Relative Density.1.143 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (237.8 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9725 mL14.8624 mL29.7247 mL148.6237 mL
5 mM0.5945 mL2.9725 mL5.9449 mL29.7247 mL
10 mM0.2972 mL1.4862 mL2.9725 mL14.8624 mL
20 mM0.1486 mL0.7431 mL1.4862 mL7.4312 mL
50 mM0.0594 mL0.2972 mL0.5945 mL2.9725 mL
100 mM0.0297 mL0.1486 mL0.2972 mL1.4862 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

pancreatic lipaseApoptosis3,4,5-Trihydroxycinnamic acid decyl ester3,4,5Trihydroxycinnamic acid decyl ester3,4,5 Trihydroxycinnamic acid decyl ester
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