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3-Oxotirucalla-7,24-dien-21-oic acid

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Catalog No. TN2979Cas No. 82464-35-5

3-Oxotirucalla-7,24-dien-21-oic acid, the first known compound isolated from Polygonum spp., can also be obtained from the roots of Black Cohosh. This compound demonstrated potent cytotoxicity against MCF-7 cell lines.

3-Oxotirucalla-7,24-dien-21-oic acid

3-Oxotirucalla-7,24-dien-21-oic acid

😃Good
Catalog No. TN2979Cas No. 82464-35-5
3-Oxotirucalla-7,24-dien-21-oic acid, the first known compound isolated from Polygonum spp., can also be obtained from the roots of Black Cohosh. This compound demonstrated potent cytotoxicity against MCF-7 cell lines.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$769InquiryInquiry
1 mL x 10 mM (in DMSO)$928InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
3-Oxotirucalla-7,24-dien-21-oic acid, the first known compound isolated from Polygonum spp., can also be obtained from the roots of Black Cohosh. This compound demonstrated potent cytotoxicity against MCF-7 cell lines.
Targets&IC50
MCF-7 cells:27.5 μM, HIV-1:20 microg/mL
In vitro
3-Oxotirucalla-7,24-dien-21-oic acid was isolated from the dichloromethane extract of the stem of Luvunga scandens (Roxb.) Buch-Ham ex Wight & Arn, Rutaceae. The cytotoxic potential of the 3-Oxotirucalla-7,24-dien-21-oic acid was determined by MTT assay against the human breast adenocarcinoma cell line (MCF-7). 3-Oxotirucalla-7,24-dien-21-oic acid showed potent cytotoxicity against the MCF-7 cell line with IC50 values of 27.5 μM, respectively. This result suggested their potential activity as antitumor agents.[1]
Chemical Properties
Molecular Weight454.68
FormulaC30H46O3
Cas No.82464-35-5
SmilesC[C@@]12C=3[C@@]([C@]4(C)[C@@](CC3)(C(C)(C)C(=O)CC4)[H])(CC[C@@]1(C)[C@]([C@H](CCC=C(C)C)C(O)=O)(CC2)[H])[H]
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

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