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Anti-PR3 Antibody (5I261)
😃Good
Catalog No. TMAB-11704
Anti-PR3 Antibody (5I261) is a Mouse antibody targeting PR3. Anti-PR3 Antibody (5I261) can be used in IHC-P,IHC-Fr,IF,ICC/IF.
Anti-PR3 Antibody (5I261)
Anti-PR3 Antibody (5I261)
😃Good
Catalog No. TMAB-11704
Anti-PR3 Antibody (5I261) is a Mouse antibody targeting PR3. Anti-PR3 Antibody (5I261) can be used in IHC-P,IHC-Fr,IF,ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-PR3 Antibody (5I261) is a Mouse antibody targeting PR3. Anti-PR3 Antibody (5I261) can be used in IHC-P,IHC-Fr,IF,ICC/IF. |
| Ig Type | IgG |
| Clone | 5I261 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ICC/IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein A purified |
| Appearance | Lyophilized or Liquid |
| Formulation | 0.01M PBS (pH7.4) |
| Research Background | The major features of Wegener granulomatosis are necrotizing granulomatous lesions, which most often affect the upper and lower airways and are associated with vasculitis, necrotizing glomerulonephritis and pulmonary capillaritis. The antigen responsible for this disease is Proteinase 3 (PR3, P29 or myeloblastin), which is one of the antibiotic proteins of neutrophilic granules belonging to the serine protease family. It is closely related to two others: Neutrophil Elastase and azurocidin. All three genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. PR3 is a neutrophil protein which is able to cleave elastin and is involved in proliferation of human leukemia cells. PR3 is expressed specifically in immature myeloid cells and is a G-CSF-responsive protein critical to factor-independent growth. The genes for all three of the related serine protease family members are located in a cluster on the tip of the short arm of human chromosome 19. |
| Immunogen | Recombinant Protein: human PR3 |
| Gene Name | PRTN3 |
| Gene ID | |
| Protein Name | Myeloblastin |
| Function | Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. |
| Molecular Weight | Theoretical: 28 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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