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YAP-TEAD-IN-1 acetate

🥰Excellent
Catalog No. TP2160L1
Alias YAP-TEAD-IN-1 acetate (1659305-78-8 Free base)

YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.

YAP-TEAD-IN-1 acetate
Other Forms of YAP-TEAD-IN-1 acetate:
YAP-TEAD-IN-1TP21601659305-78-8
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YAP-TEAD-IN-1 acetate

🥰Excellent
Purity: 99.57%
Catalog No. TP2160L1Alias YAP-TEAD-IN-1 acetate (1659305-78-8 Free base)
YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.
Pack SizePriceAvailabilityQuantity
1 mg$147In Stock
5 mg$347In Stock
10 mg$580In Stock
25 mg$928In Stock
50 mg$1,260In Stock
100 mg$1,690In Stock
500 mg$3,420In Stock
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Purity:99.57%
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COA HPLC MS

Product Introduction

Bioactivity
Description
YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.
In vitro
YAP-TEAD-IN-1 acetate (2 μM) shows a higher binding affinity to TEAD1 (Kd = 15 nM) than YAP (50-171) (Kd = 40 nM)[1].
SynonymsYAP-TEAD-IN-1 acetate (1659305-78-8 Free base)
Chemical Properties
Molecular Weight2079.92
FormulaC95H148ClN23O23S2
SmilesO=C(N(CCC1)[C@@H]1C(N[C@@H](C(N)=O)CCC(O)=O)=O)[C@H](CCC2)N2C([C@H](CCCCN)NC([C@H](CSSCC[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H]3CCCCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)NC([C@H](CC4=CC(Cl)=CC=C4)NC([C@H](CCC5)N5C([C@H](C(C)C)NC(C)=O)=O)=O)=O)NC([C@@H](NC([C@@](NC([C@@H](NC([C@@](CCC6)([H])N6C([C@](NC3=O)([H])CCCC)=O)=O)C)=O)([H])CO)=O)CC7=CC=CC=C7)=O)=O)=O.CC(O)=O
Relative Density.no data available
SequenceAc-Val-Pro-Phe(3-Cl)-Hcy(1)-Leu-Arg-Lys-Nle-Pro-Ala-Ser-Phe-Cys(1)-Lys-Pro-Pro-Glu
Sequence ShortVPXXLRKXPASFCKPPE
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 100 mg/mL (48.08 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.4808 mL2.4039 mL4.8079 mL24.0394 mL
5 mM0.0962 mL0.4808 mL0.9616 mL4.8079 mL
10 mM0.0481 mL0.2404 mL0.4808 mL2.4039 mL
20 mM0.0240 mL0.1202 mL0.2404 mL1.2020 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

YAP-TEAD-IN-1 AcetateYAPTEADIN1 acetateYAP–TEADYAP TEAD IN 1 acetate1659305-78-8 Free base1659305-78-8
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