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IKs124
🥰Excellent
Catalog No. T27593Cas No. 199335-15-4
Alias IKs-124, IKs 124
IKs124 is a KCNE2/KCNQ1 potassium channel blocker with an IC50 = 8 nM, as well as an IC50 of 370 nM and 440 nM for KCNE1 and KCNE3, respectively, and can be used to study peptic ulcers.
IKs124
🥰Excellent
Purity: 99.53%
Catalog No. T27593Alias IKs-124, IKs 124Cas No. 199335-15-4
IKs124 is a KCNE2/KCNQ1 potassium channel blocker with an IC50 = 8 nM, as well as an IC50 of 370 nM and 440 nM for KCNE1 and KCNE3, respectively, and can be used to study peptic ulcers.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,500 | In Stock |
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Purity:99.53%
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Product Introduction
Bioactivity
Chemical Properties
| Description | IKs124 is a KCNE2/KCNQ1 potassium channel blocker with an IC50 = 8 nM, as well as an IC50 of 370 nM and 440 nM for KCNE1 and KCNE3, respectively, and can be used to study peptic ulcers. |
| In vitro | IKs124 is a selective activator of KCNQ1/KCNE1 (IKs) potassium channels. In HEK293 cells expressing these channels, IKs124 enhanced IKs current in a dose-dependent manner from 0.1 to 10 μM, with maximal stimulation (~60%) observed within 5 minutes at 10 μM. IKs124 did not affect other potassium channels such as hERG or Kir2.1, demonstrating good selectivity[1]. |
| In vivo | In isolated guinea pig atrial preparations, IKs124 (1 μM) significantly shortened action potential duration (APD), with more pronounced effects at higher pacing frequencies. This indicates that IKs124 enhances repolarization via IKs activation and may be useful in treating arrhythmias associated with prolonged repolarization[1]. |
| Alias | IKs-124, IKs 124 |
| Molecular Weight | 350.48 |
| Formula | C18H26N2O3S |
| Cas No. | 199335-15-4 |
| Smiles | N#CC1=CC=C2OC(C)(C)CC(C2=C1)N(CCCC)S(=O)(=O)CC |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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