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IKs124
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Catalog No. T27593Cas No. 199335-15-4
Alias IKs-124, IKs 124
IKs124 is a KCNE2/KCNQ1 potassium channel blocker with an IC50 = 8 nM, as well as an IC50 of 370 nM and 440 nM for KCNE1 and KCNE3, respectively, and can be used to study peptic ulcers.
IKs124
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Purity: 99.53%
Catalog No. T27593Alias IKs-124, IKs 124Cas No. 199335-15-4
IKs124 is a KCNE2/KCNQ1 potassium channel blocker with an IC50 = 8 nM, as well as an IC50 of 370 nM and 440 nM for KCNE1 and KCNE3, respectively, and can be used to study peptic ulcers.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | In Stock | In Stock | |
| 5 mg | $722 | In Stock | In Stock | |
| 10 mg | $987 | In Stock | In Stock | |
| 25 mg | $1,520 | In Stock | In Stock | |
| 50 mg | $1,980 | In Stock | In Stock | |
| 100 mg | $2,500 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.53%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
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| Description | IKs124 is a KCNE2/KCNQ1 potassium channel blocker with an IC50 = 8 nM, as well as an IC50 of 370 nM and 440 nM for KCNE1 and KCNE3, respectively, and can be used to study peptic ulcers. |
| In vitro | IKs124 is a selective activator of KCNQ1/KCNE1 (IKs) potassium channels. In HEK293 cells expressing these channels, IKs124 enhanced IKs current in a dose-dependent manner from 0.1 to 10 μM, with maximal stimulation (~60%) observed within 5 minutes at 10 μM. IKs124 did not affect other potassium channels such as hERG or Kir2.1, demonstrating good selectivity[1]. |
| In vivo | In isolated guinea pig atrial preparations, IKs124 (1 μM) significantly shortened action potential duration (APD), with more pronounced effects at higher pacing frequencies. This indicates that IKs124 enhances repolarization via IKs activation and may be useful in treating arrhythmias associated with prolonged repolarization[1]. |
| Synonyms | IKs-124, IKs 124 |
| Molecular Weight | 350.48 |
| Formula | C18H26N2O3S |
| Cas No. | 199335-15-4 |
| Smiles | N#CC1=CC=C2OC(C)(C)CC(C2=C1)N(CCCC)S(=O)(=O)CC |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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