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Angiotensin II 5-valine acetate

Name: Angiotensin II 5-valine acetate
Brand: TargetMol
SKU: TP1017L1
Rating: 4.5 (1 reviews)

(Synonyms: 5-L-Valineangiotensin II acetate) Copy Product Info

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Synonyms: 5-L-Valineangiotensin II acetate

Catalog No. TP1017L1 Copy Product Info

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Angiotensin II 5-valine acts as an agonist at the angiotensin receptor.

Cas No. 5649-07-0

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Product Introduction

Bioactivity

Description	Angiotensin II 5-valine acts as an agonist at the angiotensin receptor.
In vivo	Method: Male Sprague-Dawley rats underwent uninephrectomy and were continuously infused with Angiotensin II 5-valine (40 ng/min) via subcutaneously implanted osmotic minipumps for 12 days. Some rats were concurrently treated with the AT1 receptor antagonist losartan (30 mg/kg/d) in drinking water. Exogenous Angiotensin II 5-valine was separated from endogenous Angiotensin II 5-isoleucine by high-performance liquid chromatography, and peptide contents in plasma and kidney were measured by radioimmunoassay. Result: Infusion of Angiotensin II 5-valine for 12 days significantly elevated systolic blood pressure (to 197±7 mmHg), an effect completely prevented by losartan. Renal Angiotensin II 5-valine content was markedly increased (256±44 fmol/g), with a kidney-to-plasma ratio of 6.78±1.73, indicating active renal uptake of circulating Angiotensin II 5-valine. Losartan reduced renal Angiotensin II 5-valine content by 88%, demonstrating that this uptake process is primarily mediated by AT1 receptors [1].
Synonyms	5-L-Valineangiotensin II acetate

Chemical Properties

Molecular Weight	1092.22
Formula	C₅₁H₇₃N₁₃O₁₄
Cas No.	5649-07-0
Smiles	C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(=N)N)=O)[C@H](C)C)=O)=O)C(C)C)=O)(=O)N3[C@H](C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)CCC3.C(C)(O)=O
Relative Density.	no data available
Sequence	Asp-Arg-Val-Tyr-Val-His-Pro-Phe
Sequence Short	DRVYVHPF

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Angiotensin II 5-valine acetate chemical structure | Angiotensin II 5-valine acetate in vivo | Angiotensin II 5-valine acetate formula | Angiotensin II 5-valine acetate molecular weight