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TC-S 7003

🥰Excellent
Catalog No. T15726Cas No. 847950-09-8
Alias Lck Inhibitor

TC-S 7003 (Lck Inhibitor) is an orally active, selective and potent lymphocyte kinase (Lck) inhibitor with anti-inflammatory activity, inhibition of Lck, Lyn, Src, and Syk kinases, and inhibition of T-cell proliferation, and may be useful in the study of arthritis.

TC-S 7003

TC-S 7003

🥰Excellent
Purity: 99.74%
Catalog No. T15726Alias Lck InhibitorCas No. 847950-09-8
TC-S 7003 (Lck Inhibitor) is an orally active, selective and potent lymphocyte kinase (Lck) inhibitor with anti-inflammatory activity, inhibition of Lck, Lyn, Src, and Syk kinases, and inhibition of T-cell proliferation, and may be useful in the study of arthritis.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$116In Stock
10 mg$186In Stock
25 mg$373In Stock
50 mg$618In Stock
1 mL x 10 mM (in DMSO)$136In Stock
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Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.74%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
TC-S 7003 (Lck Inhibitor) is an orally active, selective and potent lymphocyte kinase (Lck) inhibitor with anti-inflammatory activity, inhibition of Lck, Lyn, Src, and Syk kinases, and inhibition of T-cell proliferation, and may be useful in the study of arthritis.
Targets&IC50
T cells:0.53 μM, IL-2:0.46 μM
In vitro
TC-S 7003 exhibited good potency in the T-cell receptor-induced IL-2 secretion assay (IL- 2) and also inhibited subsequent T-cell proliferation (T-cell prolif.) in the same human T -cells, IL-2, IC50=0.46 μM, T-cell prolif, IC50=0.53 μM. [1]
In vivo
A once-daily dose of TC-S 7003 was administered orally at 10, 30, and 60 mg/kg from day 9 to day 17. TC-S 7003 showed a dose-dependent inhibition of arthritis (ED50=24 mg/kg). [1]
SynonymsLck Inhibitor
Chemical Properties
Molecular Weight530.62
FormulaC31H30N8O
Cas No.847950-09-8
SmilesO=C1C2=CN=C(N=C2N3C(=NC=4C=CC=CC43)N1C=5C(=CC=CC5C)C)NC6=CC=C(C=C6)N7CCN(C)CC7
Relative Density.1.36 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL(150.77 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8846 mL9.4229 mL18.8459 mL94.2294 mL
5 mM0.3769 mL1.8846 mL3.7692 mL18.8459 mL
10 mM0.1885 mL0.9423 mL1.8846 mL9.4229 mL
20 mM0.0942 mL0.4711 mL0.9423 mL4.7115 mL
50 mM0.0377 mL0.1885 mL0.3769 mL1.8846 mL
100 mM0.0188 mL0.0942 mL0.1885 mL0.9423 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

SykSrcLynLck
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