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BYK 191023 dihydrochloride

Name: BYK 191023 dihydrochloride
Brand: TargetMol
SKU: T22056
Rating: 4.5 (1 reviews)

Catalog No. T22056 Copy Product Info

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BYK 191023 dihydrochloride is a highly selective inhibitor of inducible nitric-oxide synthase (iNOS). It exerts its function by interacting directly with the catalytic center of the enzyme. Biochemical analyses have characterized BYK 191023 dihydrochloride as an NADPH- and time-dependent irreversible inhibitor. This compound is extensively utilized as a chemical tool to investigate the physiological and pathological effects mediated by iNOS in both in vitro and in vivo models, particularly concerning inflammatory responses and oxidative stress.

BYK 191023 dihydrochloride

Copy Product Info

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Catalog No. T22056

Cas No. 1216722-25-6

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Product Introduction

Bioactivity

Description	BYK 191023 dihydrochloride is a highly selective inhibitor of inducible nitric-oxide synthase (iNOS). It exerts its function by interacting directly with the catalytic center of the enzyme. Biochemical analyses have characterized BYK 191023 dihydrochloride as an NADPH- and time-dependent irreversible inhibitor. This compound is extensively utilized as a chemical tool to investigate the physiological and pathological effects mediated by iNOS in both in vitro and in vivo models, particularly concerning inflammatory responses and oxidative stress.
In vitro	BYK 191023 dihydrochloride is an NADPH-dependent, irreversible iNOS inhibitor. It selectively targets the iNOS active site, potently blocks LPS- or cytokine-induced NO production, and exhibits high selectivity for iNOS over eNOS and nNOS [1].
In vivo	In vivo, BYK 191023 dihydrochloride has been employed to evaluate the role of iNOS in models of septic shock, autoimmune diseases, and neuroinflammation. Its irreversible mode of inhibition results in long-lasting pharmacological activity, demonstrating significant efficacy in reducing tissue damage and vascular dysfunction caused by excessive iNOS activation [1].

Chemical Properties

Molecular Weight	327.21
Formula	C₁₄H₁₆Cl₂N₄O
Cas No.	1216722-25-6
Smiles	COC1=CC(CCC2=NC3=C(N2)C=CC=N3)=NC=C1.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (611.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0561 mL	15.2807 mL	30.5614 mL	152.8071 mL
5 mM	0.6112 mL	3.0561 mL	6.1123 mL	30.5614 mL
10 mM	0.3056 mL	1.5281 mL	3.0561 mL	15.2807 mL
20 mM	0.1528 mL	0.7640 mL	1.5281 mL	7.6404 mL
50 mM	0.0611 mL	0.3056 mL	0.6112 mL	3.0561 mL
100 mM	0.0306 mL	0.1528 mL	0.3056 mL	1.5281 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc