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CZC-54252 hydrochloride

Catalog No. T39202 CAS 1784253-05-9

CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.

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CZC-54252 hydrochloride Chemical Structure

CZC-54252 hydrochloride, CAS 1784253-05-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
2 mg	In stock	$ 55.00
5 mg	In stock	$ 91.00
10 mg	In stock	$ 143.00
25 mg	In stock	$ 279.00
50 mg	In stock	$ 497.00
100 mg	In stock	$ 728.00
1 mL * 10 mM (in DMSO)	In stock	$ 119.00

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Purity: 98.21%

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Description	CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.
Targets&IC50	LRRK2 (wild-type):1.28 nM (IC50), LRRK2 (G2019S):1.85 nM (IC50)
In vitro	CZC-54252 hydrochloride(1.6 nM) fully reverses G2019S LRRK2-induced human neuronal injury to wild-type levels. CZC-54252 hydrochloride inhibits the recombinant human wild-type LRRK2 with an IC50 ranging from 1 to 5 nM. CZC-54252 hydrochloride inhibits the G2019S mutant with an IC50 ranging from 2 to 7 nM in a TF-FRET assay[2].

Molecular Weight	541.45
Formula	C22H26Cl2N6O4S
CAS No.	1784253-05-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (55.41 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8. 2. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

LRRK2 inhibitor 1 BIX 02565 IKK 16 URMC-099 HG-10-102-01 GSK2578215A PF-06454589 EB-42486

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Keywords

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