IL-1 beta/IL-1F2 Protein , Human, Recombinant V2

Catalog No. TMPY-01049U

IL-1 beta/IL-1F2 Protein , Human, Recombinant V2 is expressed in E. coli. The accession number is P01584.

IL-1 beta/IL-1F2 Protein , Human, Recombinant V2

Catalog No. TMPY-01049U

IL-1 beta/IL-1F2 Protein , Human, Recombinant V2 is expressed in E. coli. The accession number is P01584.

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Product Information

Biological Activity	Measured by its ability to induce NF-kB signaling in 293-IL1 Res cells. The ED50 for this effect is 20-100 pg/ml.
Description	IL-1 beta/IL-1F2 Protein , Human, Recombinant V2 is expressed in E. coli. The accession number is P01584.
Species	Human
Expression System	E. coli
Accession Number	P01584
Synonyms	interleukin 1, β,interleukin 1, beta,IL1-β,IL1F2,IL1-BETA,IL-1B,IL-1 β,IL-1 beta,IL-1
Construction	Ala117-Ser269
Protein Purity	> 95% as determined by SDS-PAGE
Molecular Weight	17.5 kDa (Predicted); 17 kDa (Reducing conditions)
Endotoxin	< 0.01 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 7.5.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	IL1B belongs to the IL-1 family. Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and perform identical biological functions. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response. It is identified as endogenous pyrogens, and is reported to stimulate the release of prostaglandin and collagenase from synovial cells.