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Anti-SEC31A Antibody (5Y312) is a Mouse antibody targeting SEC31A. Anti-SEC31A Antibody (5Y312) can be used in WB,IHC.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $296 | 7-10 days | |
100 μL | $428 | 7-10 days |
Description | Anti-SEC31A Antibody (5Y312) is a Mouse antibody targeting SEC31A. Anti-SEC31A Antibody (5Y312) can be used in WB,IHC. |
Synonyms | Yeast Sec31p homolog, Web1 like protein, VAP1, SEC31L1, SEC31 related protein A, SEC31 like protein 1, SEC31 like 1, SEC31 homolog A (S. cerevisiae), SEC 31A, Protein transport protein Sec31A, MGC93320, MGC90305, KIAA0905, HSPC334, HSPC275, DKFZp686N07171, AU042160, ABP130, ABP125, 1810024J13Rik |
Clone | 5Y312 |
Reactivity | Human |
Verified Activity | 1. Western blot analysis of SEC31A on human SEC31A recombinant protein using anti-SEC31A antibody at 1/1,000 dilution. 2. Western blot analysis of SEC31A on HEK293 (1) and SEC31A-hIgGFc transfected HEK293 (2) cell lysate using anti-SEC31A antibody at 1/1,000 dilution. 3. Immunohistochemical analysis of paraffin-embedded human ?ovarian cancer tissue using anti-SEC31A antibody. Counter stained with hematoxylin. |
Application | |
Recommended Dose | WB: 1:500-2000; IHC: 1:50-200 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | Hybridoma Monoclonal Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. Sec31A, also known as ABP125, ABP130 or SEC31L1, is a 1,220 amino acid protein that contains seven WD repeats and localizes to the cytoplasm and to cytoplasmic vesicles, as well as to the membrane of the endoplasmic reticulum (ER). Expressed ubiquitously at high levels, Sec31A functions as a component of the COP II (coat protein II) complex and, working in tandem with other proteins, promotes the formation of ER transport vesicles and aids in the selection of cargo molecules. Chromosomal aberrations that involve the Sec31A gene are associated with inflammatory myofibroblastic tumors (IMTs), suggesting a role for Sec31A in carcinogenesis. Multiple isoforms of Sec31A exist due to alternative splicing events. |
Conjucates | Unconjugated |
Immunogen | Recombinant Protein |
Uniprot ID |
Molecular Weight | Theoretical: 133 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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