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A 68930 hydrochloride

Name: A 68930 hydrochloride
Brand: TargetMol
SKU: T21680
Rating: 4.5 (1 reviews)

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Catalog No. T21680Cas No. 130465-39-3

Alias A68930 hydrochloride

A 68930 hydrochloride is a selective dopamine D1 receptor agonist that ameliorates Aβ1–42-induced cognitive impairment and neuroinflammation in mouse models, highlighting its relevance to Alzheimer’s disease research, and at concentrations of 10–50 μg/mL also inhibits gastric H⁺/K⁺-ATPase activity comparably to omeprazole, supporting multifunctional pharmacological investigations.

A 68930 hydrochloride

😃Good

Catalog No. T21680Alias A68930 hydrochlorideCas No. 130465-39-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$716	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	A 68930 hydrochloride is a selective dopamine D1 receptor agonist that ameliorates Aβ1–42-induced cognitive impairment and neuroinflammation in mouse models, highlighting its relevance to Alzheimer’s disease research, and at concentrations of 10–50 μg/mL also inhibits gastric H⁺/K⁺-ATPase activity comparably to omeprazole, supporting multifunctional pharmacological investigations.
In vitro	In NCI-H292 cells and primary human airway epithelial cells, treatment with A 68930 hydrochloride at a concentration of 10 μM rapidly induced the time-dependent phosphorylation of CREB and significantly upregulated the mRNA and protein expression of MUC5AC[1].
Synonyms	A68930 hydrochloride

Chemical Properties

Molecular Weight	307.77
Formula	C₁₆H₁₈ClNO₃
Cas No.	130465-39-3
Smiles	C(N)[C@H]1C=2C(C[C@H](O1)C3=CC=CC=C3)=C(O)C(O)=CC2.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (259.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2492 mL	16.2459 mL	32.4918 mL	162.4590 mL
5 mM	0.6498 mL	3.2492 mL	6.4984 mL	32.4918 mL
10 mM	0.3249 mL	1.6246 mL	3.2492 mL	16.2459 mL
20 mM	0.1625 mL	0.8123 mL	1.6246 mL	8.1229 mL
50 mM	0.0650 mL	0.3249 mL	0.6498 mL	3.2492 mL
100 mM	0.0325 mL	0.1625 mL	0.3249 mL	1.6246 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc