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YNT-185

Name: YNT-185
Brand: TargetMol
SKU: T39229
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39229Cas No. 1804978-81-1

YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R. Additionally, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models.

YNT-185

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Purity: 99.67%

Catalog No. T39229Cas No. 1804978-81-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$60	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$239	In Stock	In Stock
25 mg	$478	In Stock	In Stock
50 mg	$772	In Stock	In Stock
100 mg	$1,050	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R. Additionally, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models.
Targets&IC50	OX1 receptor:2.75 μM(EC50), OX2 recepter:0.028(EC50)
In vivo	YNT-185 (20-40 mg/kg; i.p.) enhances alertness in mice. In a dose-dependent manner, YNT-185 (300 nmol; i.c.v.) significantly extends wakefulness for 3 hours and reduces non-rapid eye movement (NREM) sleep duration in wild-type mice but not in OXRDKO mice.[1]

Chemical Properties

Molecular Weight	615.74
Formula	C₃₃H₃₇N₅O₅S
Cas No.	1804978-81-1
Smiles	S(NC1=CC(NCCNC(=O)C2=C(N(C)C)C=CC=C2)=CC=C1)(=O)(=O)C3=C(OC)C=CC(=C3)C4=CC(C(N(C)C)=O)=CC=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62 mg/mL (100.69 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (4.06 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6241 mL	8.1203 mL	16.2406 mL	81.2031 mL
5 mM	0.3248 mL	1.6241 mL	3.2481 mL	16.2406 mL
10 mM	0.1624 mL	0.8120 mL	1.6241 mL	8.1203 mL
20 mM	0.0812 mL	0.4060 mL	0.8120 mL	4.0602 mL
50 mM	0.0325 mL	0.1624 mL	0.3248 mL	1.6241 mL
100 mM	0.0162 mL	0.0812 mL	0.1624 mL	0.8120 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc