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GW791343 dihydrochloride

Name: GW791343 dihydrochloride
Brand: TargetMol
SKU: T7805
Rating: 4.5 (1 reviews)

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Catalog No. T7805Cas No. 1019779-04-4

Alias GW791343 (HCl)

GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.

GW791343 dihydrochloride

😃Good

Catalog No. T7805Alias GW791343 (HCl)Cas No. 1019779-04-4

GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	Backorder	Backorder
10 mg	$68	Backorder	Backorder
25 mg	$130	Backorder	Backorder
50 mg	$226	Backorder	Backorder
100 mg	Preferential	Backorder	Backorder
1 mL x 10 mM (in DMSO)	$44	Backorder	Backorder

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

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COA

Product Introduction

Bioactivity

Description	GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.
Targets&IC50	P2X7 Receptor:6.9-7.2 (pIC50)
In vitro	GW791343 were non-competitive inhibitors of human P2X(7) receptors.?Receptor protection studies using decavanadate and pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) showed that neither compound-17 nor GW791343 competitively interacted at the ATP binding site and so were probably negative allosteric modulators of the P2X(7) receptor.?GW791343 prevented the slowly reversible blockade of the human P2X(7) receptor produced by compound-17 and inhibited [(3)H]-compound-17 binding to the P2X(7) receptor suggesting they may bind to similar or interacting sites[1].
Synonyms	GW791343 (HCl)

Chemical Properties

Molecular Weight	447.35
Formula	C₂₀H₂₆Cl₂F₂N₄O
Cas No.	1019779-04-4
Smiles	Cl.Cl.Cc1ccc(CN2CCNCC2)cc1NC(=O)CNc1ccc(F)c(F)c1
Relative Density.	no data available
Color	White
Appearance	solid

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 42 mg/mL (93.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2354 mL	11.1769 mL	22.3539 mL	111.7693 mL
5 mM	0.4471 mL	2.2354 mL	4.4708 mL	22.3539 mL
10 mM	0.2235 mL	1.1177 mL	2.2354 mL	11.1769 mL
20 mM	0.1118 mL	0.5588 mL	1.1177 mL	5.5885 mL
50 mM	0.0447 mL	0.2235 mL	0.4471 mL	2.2354 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc