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GW791343 dihydrochloride

Name: GW791343 dihydrochloride
Brand: TargetMol
SKU: T7805
Rating: 4.5 (1 reviews)

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Catalog No. T7805Cas No. 1019779-04-4

Alias GW791343 (HCl)

GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.

GW791343 dihydrochloride

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Catalog No. T7805Alias GW791343 (HCl)Cas No. 1019779-04-4

GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	Inquiry	Inquiry
10 mg	$68	Inquiry	Inquiry
25 mg	$130	Inquiry	Inquiry
50 mg	$226	Inquiry	Inquiry
100 mg	Preferential	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$44	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:solid

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COA

Product Introduction

Bioactivity

Description	GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.
Targets&IC50	P2X7 Receptor:6.9-7.2 (pIC50)
In vitro	GW791343 were non-competitive inhibitors of human P2X(7) receptors.?Receptor protection studies using decavanadate and pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) showed that neither compound-17 nor GW791343 competitively interacted at the ATP binding site and so were probably negative allosteric modulators of the P2X(7) receptor.?GW791343 prevented the slowly reversible blockade of the human P2X(7) receptor produced by compound-17 and inhibited [(3)H]-compound-17 binding to the P2X(7) receptor suggesting they may bind to similar or interacting sites[1].
Synonyms	GW791343 (HCl)

Chemical Properties

Molecular Weight	447.35
Formula	C₂₀H₂₆Cl₂F₂N₄O
Cas No.	1019779-04-4
Smiles	Cl.Cl.Cc1ccc(CN2CCNCC2)cc1NC(=O)CNc1ccc(F)c(F)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 42 mg/mL (93.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2354 mL	11.1769 mL	22.3539 mL	111.7693 mL
5 mM	0.4471 mL	2.2354 mL	4.4708 mL	22.3539 mL
10 mM	0.2235 mL	1.1177 mL	2.2354 mL	11.1769 mL
20 mM	0.1118 mL	0.5588 mL	1.1177 mL	5.5885 mL
50 mM	0.0447 mL	0.2235 mL	0.4471 mL	2.2354 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc