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Sulfamerazine

Name: Sulfamerazine
Brand: TargetMol
SKU: T0913
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0913Cas No. 127-79-7

Alias RP2632

Sulfamerazine (RP2632) is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for the binding site on dihydropteroate synthase.

Sulfamerazine

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Purity: 99.78%

Catalog No. T0913Alias RP2632Cas No. 127-79-7

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	In Stock	In Stock
500 mg	$58	In Stock	In Stock
1 g	$97	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.78%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Sulfamerazine (RP2632) is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for the binding site on dihydropteroate synthase.
In vitro	Sulfamerazine significantly affects the lifespan of rats, markedly prolonging the life of male hamsters. The maximum body weight of all rats fed with sulfamerazine exceeded that of the control group. After oral administration of sulfamerazine, significant alterations in the shape of the concentration-time curve due to age were observed, strongly indicating absorption deficiencies within the first week after birth in lambs.
In vivo	Sulfamerazine exhibits a bi-exponential decay in water and a tri-exponential decay in cyclodextrin (CD) solutions. The resonance of aromatic protons in Sulfamerazine indicates a significant upfield shift, suggesting that the aniline ring is deeply encapsulated within the CD cavity.
Synonyms	RP2632

Chemical Properties

Molecular Weight	264.30
Formula	C₁₁H₁₂N₄O₂S
Cas No.	127-79-7
Smiles	CC1=NC(NS(=O)(=O)C2=CC=C(N)C=C2)=NC=C1
Relative Density.	1.439 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (227.01 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7836 mL	18.9179 mL	37.8358 mL	189.1790 mL
5 mM	0.7567 mL	3.7836 mL	7.5672 mL	37.8358 mL
10 mM	0.3784 mL	1.8918 mL	3.7836 mL	18.9179 mL
20 mM	0.1892 mL	0.9459 mL	1.8918 mL	9.4589 mL
50 mM	0.0757 mL	0.3784 mL	0.7567 mL	3.7836 mL
100 mM	0.0378 mL	0.1892 mL	0.3784 mL	1.8918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc