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Euphorbia factor L1

Name: Euphorbia factor L1
Brand: TargetMol
SKU: T2S0410
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S0410Cas No. 76376-43-7

Alias Euphorbiasteroid

Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.

Euphorbia factor L1

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Purity: 99.74%

Catalog No. T2S0410Alias EuphorbiasteroidCas No. 76376-43-7

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$163	In Stock	In Stock
100 mg	$239	-	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.74%

Color:White

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Product Introduction

Bioactivity

Description	Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.
In vitro	Euphorbiasteroid suppresses adipogenic differentiation of 3T3‐L1 cells, mainly at the early stage, and stimulates the AMPK signalling pathway. The anti-adipogenic effects of euphorbiasteroid could possibly be attributed to activation of the AMPK pathway, by decreasing the level of FAS and its up-regulators, including C/EBPs, PPAR-γ and SREBP-1c, without involving insulin signalling pathway[1]. Euphorbiasteroid could be a transport substrate for P-gp that can effectively inhibit P-gp-mediated drug transport and reverse resistance to anticancer drugs in MES-SA/Dx5 cells[2].
Cell Research	3T3‐L1 cells were treated with euphorbiasteroid at concentrations of 6.25, 12.5, 25 and 50?μM for 2?days in adipogenesis induction medium, 2?days in adipogenesis medium and 2?days in culture medium (CM) sequentially during differentiation. Intracellular triglycerides (TGs) were stained with Oil red O (ORO) solution.
Synonyms	Euphorbiasteroid

Chemical Properties

Molecular Weight	552.66
Formula	C₃₂H₄₀O₈
Cas No.	76376-43-7
Smiles	O(C(C)=O)[C@]12[C@@]([C@@H](OC(C)=O)[C@@]3(CO3)CC[C@]4([C@@](\C=C(\C)/C1=O)(C4(C)C)[H])[H])([C@@H](OC(CC5=CC=CC=C5)=O)[C@@H](C)C2)[H]
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: Soluble

DMSO: 37 mg/mL (66.95 mM), Sonication is recommended.

Ethanol: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8094 mL	9.0472 mL	18.0943 mL	90.4715 mL
5 mM	0.3619 mL	1.8094 mL	3.6189 mL	18.0943 mL
10 mM	0.1809 mL	0.9047 mL	1.8094 mL	9.0472 mL
20 mM	0.0905 mL	0.4524 mL	0.9047 mL	4.5236 mL
50 mM	0.0362 mL	0.1809 mL	0.3619 mL	1.8094 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc