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Anti-JAK3 Antibody (8C887)
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Catalog No. TMAH-00656
Alias Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2
Anti-JAK3 Antibody (8C887) is an antibody targeting JAK3. Anti-JAK3 Antibody (8C887) can be used in ELISA, IHC.
Anti-JAK3 Antibody (8C887)
Anti-JAK3 Antibody (8C887)
😃Good
Catalog No. TMAH-00656Alias Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2
Anti-JAK3 Antibody (8C887) is an antibody targeting JAK3. Anti-JAK3 Antibody (8C887) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-JAK3 Antibody (8C887) is an antibody targeting JAK3. Anti-JAK3 Antibody (8C887) can be used in ELISA, IHC. |
| Alias | Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2 |
| Ig Type | Rabbit IgG |
| Clone | 8C887 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00656 diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Endomembrane system; Peripheral membrane protein. Cytoplasm. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human JAK3 |
| Antigen Species | Human |
| Gene ID | 3718 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Cancer, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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