Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 51.00 | |
10 mg | In stock | $ 80.00 | |
25 mg | In stock | $ 172.00 | |
50 mg | In stock | $ 278.00 | |
100 mg | In stock | $ 455.00 |
Description | TDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration. |
In vitro | TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation; TDI-011536 (3 µM; 5 days) induces proliferation of Müller glia in human retinal organoids[1]. |
In vivo | TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs[1]. TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1]. |
Molecular Weight | 364.42 |
Formula | C19H16N4O2S |
CAS No. | 2687970-96-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL(274.41 mM)
You can also refer to dose conversion for different animals. More
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TDI-011536 2687970-96-1 Others TDI 011536 TDI011536 inhibitor inhibit