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TDI-011536

Name: TDI-011536
Brand: TargetMol
SKU: T60144
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60144Cas No. 2687970-96-1

TDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration.

TDI-011536

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Purity: 99.83%

Catalog No. T60144Cas No. 2687970-96-1

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$51	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$172	In Stock	In Stock
50 mg	$278	In Stock	In Stock
100 mg	$455	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	TDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration.
In vitro	TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces Müller glia proliferation in human retinal organoids[1].
In vivo	TDI-011536 (200 mg/kg; i.p.; once) inhibits Lats and reduces pYap levels for over 4 hours in the liver, heart, and skin, while TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) exhibits a proliferative effect on cardiomyocytes[1].

Chemical Properties

Molecular Weight	364.42
Formula	C₁₉H₁₆N₄O₂S
Cas No.	2687970-96-1
Smiles	OCc1cs\c(=N/C(=O)c2c[nH]c3ncccc23)n1Cc1ccccc1
Relative Density.	1.41 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (137.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7441 mL	13.7204 mL	27.4409 mL	137.2043 mL
5 mM	0.5488 mL	2.7441 mL	5.4882 mL	27.4409 mL
10 mM	0.2744 mL	1.3720 mL	2.7441 mL	13.7204 mL
20 mM	0.1372 mL	0.6860 mL	1.3720 mL	6.8602 mL
50 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7441 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3720 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc