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TDI-011536

Name: TDI-011536
Brand: TargetMol
SKU: T60144
Price: 51 USD
Availability: InStock
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Catalog No. T60144Cas No. 2687970-96-1

TDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration.

TDI-011536

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Purity: 99.83%

Catalog No. T60144Cas No. 2687970-96-1

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$51	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$172	In Stock	In Stock
50 mg	$278	In Stock	In Stock
100 mg	$455	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration.
In vitro	TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces Müller glia proliferation in human retinal organoids[1].
In vivo	TDI-011536 (200 mg/kg; i.p.; once) inhibits Lats and reduces pYap levels for over 4 hours in the liver, heart, and skin, while TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) exhibits a proliferative effect on cardiomyocytes[1].

Chemical Properties

Molecular Weight	364.42
Formula	C₁₉H₁₆N₄O₂S
Cas No.	2687970-96-1
Smiles	OCc1cs\c(=N/C(=O)c2c[nH]c3ncccc23)n1Cc1ccccc1
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33.93 mg/mL (93.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7441 mL	13.7204 mL	27.4409 mL	137.2043 mL
5 mM	0.5488 mL	2.7441 mL	5.4882 mL	27.4409 mL
10 mM	0.2744 mL	1.3720 mL	2.7441 mL	13.7204 mL
20 mM	0.1372 mL	0.6860 mL	1.3720 mL	6.8602 mL
50 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7441 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc