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Anti-Uromodulin/Umod Polyclonal Antibody
(Synonyms: Uromodulin, Umod, Tamm-Horsfall urinary glycoprotein (THP)) Copy Product Info
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Synonyms: Uromodulin, Umod, Tamm-Horsfall urinary glycoprotein (THP)
Catalog No. TMAB-01939 Copy Product Info
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Anti-Uromodulin/Umod Polyclonal Antibody is a Rabbit antibody targeting Uromodulin/Umod. Anti-Uromodulin/Umod Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Anti-Uromodulin/Umod Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Uromodulin/Umod Polyclonal Antibody is a Rabbit antibody targeting Uromodulin/Umod. Anti-Uromodulin/Umod Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | Uromodulin, Umod, Tamm-Horsfall urinary glycoprotein (THP) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:400-800; IHC-Fr: 1:400-800; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Apical cell membrane; Lipid-anchor, GPI-anchor (By similarity). Basolateral cell membrane; Lipid-anchor, GPI-anchor (By similarity). Cell projection, cilium membrane (By similarity). Note=Only a small fraction is sorts to the basolateral pole of tubular epithelial cells compared to apical localization (By similarity).Uromodulin, secreted form: Secreted (By similarity). |
| Tissue Specificity | Synthesized exclusively in the kidney.Expressed exclusively by epithelial cells of the thick ascendinglimb of Henle's loop (TALH) and of distal convoluted tubule lumen.Most abundant protein in normal urine. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]. |
| Immunogen | KLH conjugated synthetic peptide: mouse UMOD |
| Antigen Species | Mouse |
| Gene Name | UMOD |
| Protein Name | Uromodulin |
| Biology Area | Other Antibodies |
| Function | Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial (By similarity).Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals. |
| Molecular Weight | Theoretical: 61/65 kDa. Actual: 37 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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