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SIRP alpha Protein, Mouse, Recombinant (MIgG2a)
(Synonyms: Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, SIRPA, SIRP, Signal-Regulatory Protein α-1, Signal-Regulatory Protein Alpha-1, SHPS1, MFR, CD172a, CD172 Antigen-Like Family Member A) Copy Product InfoSynonyms: Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, SIRPA, SIRP, Signal-Regulatory Protein α-1, Signal-Regulatory Protein Alpha-1, SHPS1, MFR, CD172a, CD172 Antigen-Like Family Member A
Catalog No. TMPJ-01182 Copy Product Info
SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $72 | 35 days | 35 days | |
| 10 μg | $116 | 35 days | 35 days | |
| 20 μg | $176 | 35 days | 35 days | |
| 50 μg | $310 | 35 days | 35 days | |
| 100 μg | $532 | 35 days | 35 days | |
| 200 μg | $919 | 35 days | 35 days | |
| 500 μg | $1,900 | 35 days | 35 days | |
| 1 mg | $2,730 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-mIgG2a Fc |
| Accession Number | P97797-2 |
| Amino Acid | Lys32-Asn373 |
| Construction | Lys32-Asn373 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, SIRPA, SIRP, Signal-Regulatory Protein α-1, Signal-Regulatory Protein Alpha-1, SHPS1, MFR, CD172a, CD172 Antigen-Like Family Member A |
| Research Background |
| Molecular Weight | 90-120 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: SIRP alpha Protein, Mouse, Recombinant (MIgG2a) chemical structure | SIRP alpha Protein, Mouse, Recombinant (MIgG2a) molecular weight
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