SIGIRR Protein, Human, Recombinant (His), Biotinylated

Name: SIGIRR Protein, Human, Recombinant (His), Biotinylated
Brand: TargetMol
SKU: TMPY-06898
Rating: 4.5 (1 reviews)

(Synonyms: TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain) Copy Product Info

Synonyms: TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Catalog No. TMPY-06898 Copy Product Info

SIGIRR Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.98 kDa and the accession number is Q6IA17-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$172	7-10 days	7-10 days
10 µg	$298	7-10 days	7-10 days
20 µg	$498	7-10 days	7-10 days
50 µg	$823	7-10 days	7-10 days
100 µg	$1,380	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	SIGIRR Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.98 kDa and the accession number is Q6IA17-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q6IA17-1
Construction	A DNA sequence encoding the Human SIGIRR (Q6IA17-1) (Met1-His118) was expressed, fused with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro. Predicted N terminal: Met 1
Protein Purity	≥ 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Research Background	Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.

Chemical Properties

Molecular Weight

13.98 kDa (predicted); 28.45 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

TIR-8TIR 8

Related Tags: SIGIRR Protein, Human, Recombinant (His), Biotinylated chemical structure | SIGIRR Protein, Human, Recombinant (His), Biotinylated molecular weight