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Cystamine dihydrochloride

Name: Cystamine dihydrochloride
Brand: TargetMol
SKU: T20109
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20109Cas No. 56-17-7

Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.

Cystamine dihydrochloride

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Purity: 99.81%

Catalog No. T20109Cas No. 56-17-7

Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.

Pack Size	Price	USA Warehouse	Global Warehouse
25 g	$30	-	In Stock
50 g	$50	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.81%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Cystamine dihydrochloride AI Summary

Cystamine dihydrochloride exhibits a range of bioactivities, including potent inhibition of the proliferation of Plasmodium falciparum line 3D7 with an IC50 of 8912.5 nM. It serves as an inhibitor of Tyrosyl-DNA Phosphodiesterase (TDP1) with IC50 values of 28183.8 nM and 1778.3 nM. Additionally, Cystamine dihydrochloride inhibits Tau Fibril Formation, with potencies between 12589.3 nM and 14125.4 nM. It is also effective as a cell-membrane permeable IMPase inhibitor, showing potency at 5623.4 nM. Furthermore, the compound displays inhibitory activities on Fructose-1,6-bisphosphate Aldolase, MPP8 Chromodomain Interactions, Histone Lysine Methyltransferase G9a, vitamin D receptor (VDR), Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), and Marburg Virus entry, with potencies spanning from 44.7 nM to 79432.8 nM. In terms of transporter interactions, Cystamine dihydrochloride strongly inhibits sodium fluorescein uptake, demonstrating an 89.2% inhibition in OATP1B3-transfected CHO cells and 111.28% in OATP1B1-transfected CHO cells at a 10 µM concentration, indicating its capacity to interfere with the transport mechanisms mediated by these transporters. Additionally, Cystamine dihydrochloride acts as an inhibitor of histone lysine methyltransferases G9a with an IC50 of 15000.0 nM, albeit showing weaker inhibition of GLP, with an IC50 greater than 100000.0 nM. It also has a weak to negligible inhibitory effect on ALDH1A1, as evidenced by an IC50 value exceeding 100000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.
Targets&IC50	Caspase-3:23.6 μM

Chemical Properties

Molecular Weight	225.19
Formula	C₄H₁₄Cl₂N₂S₂
Cas No.	56-17-7
Smiles	C(CSSCCN)N.Cl.Cl
Relative Density.	1.172g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (222.03 mM), Sonication is recommended.

H2O: 50 mg/mL (222.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.4407 mL	22.2035 mL	44.4069 mL	222.0347 mL
5 mM	0.8881 mL	4.4407 mL	8.8814 mL	44.4069 mL
10 mM	0.4441 mL	2.2203 mL	4.4407 mL	22.2035 mL
20 mM	0.2220 mL	1.1102 mL	2.2203 mL	11.1017 mL
50 mM	0.0888 mL	0.4441 mL	0.8881 mL	4.4407 mL
100 mM	0.0444 mL	0.2220 mL	0.4441 mL	2.2203 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc