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(S)-(+)-Ibuprofen

Name: (S)-(+)-Ibuprofen
Brand: TargetMol
SKU: T0448
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0448Cas No. 51146-56-6

Alias Dexibuprofen, (S)-Ibuprofen

(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).

(S)-(+)-Ibuprofen

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Purity: 99.86%

Catalog No. T0448Alias Dexibuprofen, (S)-IbuprofenCas No. 51146-56-6

(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$35	In Stock	In Stock
5 g	$77	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.86%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

(S)-(+)-Ibuprofen AI Summary

(S)-(+)-Ibuprofen exhibits diverse bioactivities, including anti-inflammatory, antiviral, and enzyme inhibitory properties. It demonstrates significant anti-inflammatory activity, as evidenced by its effective dose (ED50) of 7.08 mg/kg in a rat hind paw edema model and notable selectivity toward cyclooxygenase II (COX-2) over cyclooxygenase I (COX-1) with a selectivity ratio of 117.5. The compound inhibits pro-inflammatory enzymes such as COX-1 (IC50 of 105.0 nM) and COX-2 (IC50 of 1,500.0 nM), and shows a selectivity index of 1.83 for COX-2 over COX-1. In addition to its anti-inflammatory effects, (S)-(+)-Ibuprofen inhibits CXCL8-induced chemotaxis of human polymorphonuclear cells (IC50 100.0 nM) and lipopolysaccharide-induced PGE-2 production (>99% at 10µM). In terms of enzyme inhibition, (S)-(+)-Ibuprofen affects acetylcholine esterase, various aldo-keto reductases (AKRs), and ASIC channels. It inhibits Fischer 344 rat brain acetylcholine esterase (20% inhibition at 0.6 mM) and AKR1C2, AKR1C3 with IC50 values of 42400.0 nM and 32700.0 nM respectively, while showing moderate activity against ASIC3 and ASIC1a receptors. The compound also demonstrates antiviral activities, including modest inhibition of SARS-CoV-2 in Vero E6 and Caco-2 cell assays. It exhibits an inhibition percentage of 9.369% on the SARS-CoV-2 3CL-Pro protease at a concentration of 20µM. Pharmacokinetic properties of (S)-(+)-Ibuprofen show an oral bioavailability of 80% in humans and good plasma concentration (96% at 30 µg/mL). It has acceptable lipid solubility with a LogD of 1.07 at pH 7.4 and a dissociation constant (pKa) of 5.2. Overall, (S)-(+)-Ibuprofen's profile suggests potential applications in therapeutic areas requiring anti-inflammatory, antiviral, and enzyme inhibitory actions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
Targets&IC50	COX-2:370 μM, COX-1:13 μM
Synonyms	Dexibuprofen, (S)-Ibuprofen

Chemical Properties

Molecular Weight	206.28
Formula	C₁₃H₁₈O₂
Cas No.	51146-56-6
Smiles	CC(C)CC1=CC=C(C=C1)[C@H](C)C(O)=O
Relative Density.	1.029 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (121.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8478 mL	24.2389 mL	48.4778 mL	242.3890 mL
5 mM	0.9696 mL	4.8478 mL	9.6956 mL	48.4778 mL
10 mM	0.4848 mL	2.4239 mL	4.8478 mL	24.2389 mL
20 mM	0.2424 mL	1.2119 mL	2.4239 mL	12.1194 mL
50 mM	0.0970 mL	0.4848 mL	0.9696 mL	4.8478 mL
100 mM	0.0485 mL	0.2424 mL	0.4848 mL	2.4239 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc