Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Histone Acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.

A-485
T140731889279-16-6
A-485 is a potent and selective catalytic p300 CBP inhibitor with IC50 values of 9.8 nM for p300 and 2.6 nM for CBP.
  • $89
In Stock
Size
QTY
TargetMol | Inhibitor Hot
Curcumin
T1516458-37-7
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
NEO2734
T86582081072-29-7In house
NEO2734 (EP31670) is an orally active, selective inhibitor of p300/CBP and BET bromodomains, with an IC50 of less than 30 nM for both targets.
  • $116
In Stock
Size
QTY
WM-3835
T91022229025-70-9
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
  • $31
In Stock
Size
QTY
TargetMol | Inhibitor Sale
C646
T2452328968-36-1
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
  • $41
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Pocenbrodib
T696912304372-79-8In house
Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research.
  • $790
In Stock
Size
QTY
Acetaminophen
T0065103-90-2
Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity.
  • $41
In Stock
Size
QTY
TargetMol | Citations Cited
Remodelin
T3499949912-58-7
Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.
  • $33
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
GNE-781
T154051936422-33-1
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).
  • $147
In Stock
Size
QTY
TargetMol | Citations Cited
WM-1119
T46792055397-28-7
WM-1119 is a highly potent, selective KAT6A/B inhibitor
  • $47
In Stock
Size
QTY
Butyrolactone 3
T14839778649-18-6
Butyrolactone 3 (MB-3) is a histone acetyltransferase Gcn5 inhibitor with a weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and has been used in cancer, metabolic and neurological disorders.
  • $67
In Stock
Size
QTY
MG 149
T65841243583-85-8
MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
  • $48
In Stock
Size
QTY
PF-9363
T91672569009-58-9
PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
  • $67
In Stock
Size
QTY
Anacardic Acid
T638916611-84-0
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300 CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostaglandin synthase, lipoxygenase, and tyrosinase.
  • $45
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
WM-8014
T43622055397-18-5
WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
  • $52
In Stock
Size
QTY
SGC-CBP30
T66681613695-14-9
SGC-CBP30 is an effective CREBBP EP300 inhibitor (IC50: 21 38 nM).
  • $45
In Stock
Size
QTY
TargetMol | Citations Cited
Remodelin hydrobromide
T61331622921-15-6
Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
  • $52
In Stock
Size
QTY
TargetMol | Inhibitor Sale
JG-2016
T820082887480-87-5
JG-2016, as a small molecule histone acetyltransferase 1 (HAT1) inhibitor, inhibits the growth of human cancer cell lines, inhibits enzyme activity in cellulose, and interferes with tumor growth.
  • $118
In Stock
Size
QTY
CTB
T9541451491-47-7
CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
    Inquiry
    CBL0137
    T41261197996-80-7
    CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.
    • $44
    In Stock
    Size
    QTY
    CBP/p300-IN-3
    T123452299226-01-8
    CBP p300-IN-3 (P300 CBP-IN-3) is an inhibitor of p300 CBP histone acetyltransferase.
    • $84
    In Stock
    Size
    QTY
    Procyanidin B3
    TN115023567-23-9
    Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
    • $46
    In Stock
    Size
    QTY
    MC4033
    T7815628532-21-0
    MC4033 is a selective lysine acetyltransferase 8 (KAT8) inhibitor (IC50: 12.1 μM) with anticancer effects, induces apoptosis, and can be used for the study of non-small cell lung cancer.
    • $31
    In Stock
    Size
    QTY
    CPTH2
    T8344357649-93-5
    CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
    • $31
    In Stock
    Size
    QTY