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Anti-EGFR Antibody (6Z678)
😃Good
Catalog No. TMAY-00023
Alias PIG61, NISBD2, mENA, HER1, ERBB1, ERBB, epidermal growth factor receptor
Anti-EGFR Antibody (6Z678) is a Mouse antibody targeting EGFR. Anti-EGFR Antibody (6Z678) can be used in IHC-P.
Anti-EGFR Antibody (6Z678)
Anti-EGFR Antibody (6Z678)
😃Good
Catalog No. TMAY-00023Alias PIG61, NISBD2, mENA, HER1, ERBB1, ERBB, epidermal growth factor receptor
Anti-EGFR Antibody (6Z678) is a Mouse antibody targeting EGFR. Anti-EGFR Antibody (6Z678) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-EGFR Antibody (6Z678) is a Mouse antibody targeting EGFR. Anti-EGFR Antibody (6Z678) can be used in IHC-P. |
| Alias | PIG61, NISBD2, mENA, HER1, ERBB1, ERBB, epidermal growth factor receptor |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 6Z678 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human EGFR in human rectal carcinoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human EGFR in human placenta with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). Positive staining was localized to trophoblast. 3. Immunochemical staining of human EGFR in human esophageal carcinoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; TMPY-04529; NP_005219; Met668-Ala1210). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human EGFR / HER1 / ErbB1 protein (TMPY-04529) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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