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DPA-714

Name: DPA-714
Brand: TargetMol
SKU: T15162
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15162Cas No. 958233-07-3

DPA-714 is a high-affinity translocator protein (TSPO) ligand (Ki=7 nM) designed with a fluorine atom, allowing labeling with fluorine-18 for in vivo imaging via positron emission tomography. [18F]DPA-714 successfully enables specific imaging of inflammation in various neuroinflammation models and a brain tumor model.

DPA-714

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Purity: 99.52%

Catalog No. T15162Cas No. 958233-07-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$170	In Stock	In Stock
25 mg	$315	In Stock	In Stock
50 mg	$457	-	In Stock
100 mg	$648	-	In Stock
1 mL x 10 mM (in DMSO)	$119	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

DPA-714 AI Summary

DPA-714 shows high affinity for the translocator protein (TSPO) receptor in various rat tissues, with reported Ki values ranging from 0.91 nM in rat heart membranes to 7.0 nM in rat kidney and brain cortex mitochondrial membranes. This indicates its potential bioactivity as a modulator of TSPO, a receptor involved in cellular functions such as apoptosis, inflammation, and neuroprotection. Despite its strong affinity for TSPO, DPA-714 exhibits very low affinity for the central benzodiazepine receptor (CBR), with Ki values greater than 1000.0 nM in rat cerebral cortex membranes. The compound has moderate lipophilicity, with reported LogP values from 2.12 to 2.89 at pH 7.4-7.5. Metabolic studies show that the compound is subjected to different rates of drug metabolism, with intrinsic clearance values of 68.0 uL/min in human hepatic microsomes, over 1000.0 uL/min in Sprague-Dawley rat hepatic microsomes, and 408.0 uL/min in CD1 mouse hepatic microsomes. It also demonstrates good metabolic stability in rat brain, with less than 3.0% of the parent compound remaining after 30 minutes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DPA-714 is a high-affinity translocator protein (TSPO) ligand (Ki=7 nM) designed with a fluorine atom, allowing labeling with fluorine-18 for in vivo imaging via positron emission tomography. [18F]DPA-714 successfully enables specific imaging of inflammation in various neuroinflammation models and a brain tumor model.
Targets&IC50	TSPO:(ki)7 nM

Chemical Properties

Molecular Weight	398.47
Formula	C₂₂H₂₇FN₄O₂
Cas No.	958233-07-3
Smiles	CCN(CC)C(=O)Cc1c(nn2c(C)cc(C)nc12)-c1ccc(OCCF)cc1
Relative Density.	1.18 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 41.67 mg/mL (104.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5096 mL	12.5480 mL	25.0960 mL	125.4800 mL
5 mM	0.5019 mL	2.5096 mL	5.0192 mL	25.0960 mL
10 mM	0.2510 mL	1.2548 mL	2.5096 mL	12.5480 mL
20 mM	0.1255 mL	0.6274 mL	1.2548 mL	6.2740 mL
50 mM	0.0502 mL	0.2510 mL	0.5019 mL	2.5096 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2548 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc