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Anti-BUB1B Antibody (4Y527)
(Synonyms: Protein SSK1, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, Mitotic checkpoint kinase MAD3L, MAD3/BUB1-related protein kinase, hBUBR1, EC 2.7.11.1, BUBR1 MAD3L SSK1, BUB 1B) Copy Product Info
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Synonyms: Protein SSK1, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, Mitotic checkpoint kinase MAD3L, MAD3/BUB1-related protein kinase, hBUBR1, EC 2.7.11.1, BUBR1 MAD3L SSK1, BUB 1B
Catalog No. TMAH-00125 Copy Product Info
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Anti-BUB1B Antibody (4Y527) is an antibody targeting BUB1B. Anti-BUB1B Antibody (4Y527) can be used in ELISA,FCM,WB.
Anti-BUB1B Antibody
(4Y527)
(4Y527)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $209 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-BUB1B Antibody (4Y527) is an antibody targeting BUB1B. Anti-BUB1B Antibody (4Y527) can be used in ELISA,FCM,WB. |
| Synonyms | Protein SSK1, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, Mitotic checkpoint kinase MAD3L, MAD3/BUB1-related protein kinase, hBUBR1, EC 2.7.11.1, BUBR1 MAD3L SSK1, BUB 1B |
| Ig Type | Rabbit IgG |
| Clone | 4Y527 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB:1:500-1:5000; FCM:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and KNL1. |
| Tissue Specificity | Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human BubR1 |
| Antigen Species | Human |
| Gene Name | BUB1B |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Cancer, Cell biology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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