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Endothelin-1 (1-31) (Human) TFA

Catalog No. T78063

Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from the chymase-mediated selective hydrolysis of big ET-1 [1].

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Endothelin-1 (1-31) (Human) TFA Chemical Structure

Endothelin-1 (1-31) (Human) TFA, CAS N/A

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Description	Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from the chymase-mediated selective hydrolysis of big ET-1 [1].
In vitro	Endothelin-1 (1-31) (Human) at concentrations ranging from 100 pM to 100 nM over a 24-hour period induces proliferation of human mesangial cells [2]. Additionally, Endothelin-1 (1-31) (Human) at a concentration of 100 nM triggers ERK activation in human mesangial cells within a timeframe of 0 to 10 minutes [2].
In vivo	ET-1 (1-31) (100 nM; single dose) TFA induces constriction of the mesenteric arteries in mice. This vasoconstriction is likely mediated by ET A receptors and may increase with age. Notable gender differences have been observed in the context of current chronic diabetes [1].

Molecular Weight	3742.18
Formula	C164H237F3N38O49S5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Endothelin-1 (1-31) (Human) TFA MAPK ERK inhibitor inhibit

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