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CDK1-IN-8
Catalog No. T214134 Copy Product Info
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CDK1-IN-8 is an inhibitor of CDK1. It effectively hinders cell migration, induces apoptosis, and arrests the cell cycle at the G2/M phase. CDK1-IN-8 significantly reduces the expression level of CDK1 protein in HepG2 cells and can be utilized in research related to human hepatocellular carcinoma.
CDK1-IN-8
Copy Product Info🥰Excellent
Catalog No. T214134
CDK1-IN-8 is an inhibitor of CDK1. It effectively hinders cell migration, induces apoptosis, and arrests the cell cycle at the G2/M phase. CDK1-IN-8 significantly reduces the expression level of CDK1 protein in HepG2 cells and can be utilized in research related to human hepatocellular carcinoma.
CDK1-IN-8
Cas No. 3077717-99-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | CDK1-IN-8 is an inhibitor of CDK1. It effectively hinders cell migration, induces apoptosis, and arrests the cell cycle at the G2/M phase. CDK1-IN-8 significantly reduces the expression level of CDK1 protein in HepG2 cells and can be utilized in research related to human hepatocellular carcinoma. |
| In vitro | CDK1-IN-8 (Compound c9) exhibits the strongest inhibitory activity against HepG2 cells, with an IC50 of 11.88 μM. In normal L02 liver cells, the IC50 is 95.48 μM, giving a selectivity index (SI) of 8.0. When used at 10-20 μM for 48 hours, CDK1-IN-8 significantly impairs the in vitro migration capability of HepG2 cells, indicating its potential in combating tumor metastasis. At concentrations of 0-5 μM for 48 hours, it induces notable dose-dependent apoptosis in HepG2 cells. Furthermore, CDK1-IN-8 (0-15 μM, 48 h) inhibits proliferation by causing cell cycle arrest in the G2/M phase in HepG2 cells. Additionally, at 2.5-15 μM, over 48 hours, it significantly reduces the expression level of CDK1 protein in a dose-dependent manner in HepG2 cells. |
| Molecular Weight | 604.95 |
| Formula | C28H27ClFN2O8P |
| Cas No. | 3077717-99-5 |
| Smiles | O=C(NCCNC(C1=CC=C(Cl)C(F)=C1)P(=O)(OCC)OCC)C2=CC(O)=C3C(=O)C=4C(O)=CC=CC4C(=O)C3=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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