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ALKBH5-IN-5

🥰Excellent
Catalog No. T203011Cas No. 140481-05-6

ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor (IC50 = 0.62 μM) that alters m6A levels on mRNA, promotes differentiation and induces apoptosis, with antitumor activity.ALKBH5 is an N6-methyladenosine (m6A) demethylase that is closely related to leukemogenesis.

ALKBH5-IN-5

ALKBH5-IN-5

🥰Excellent
Purity: 99.54%
Catalog No. T203011Cas No. 140481-05-6
ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor (IC50 = 0.62 μM) that alters m6A levels on mRNA, promotes differentiation and induces apoptosis, with antitumor activity.ALKBH5 is an N6-methyladenosine (m6A) demethylase that is closely related to leukemogenesis.
Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$40In Stock
25 mg$81In Stock
50 mg$129In Stock
100 mg$198In Stock
200 mg$297In Stock
1 mL x 10 mM (in DMSO)$44In Stock
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Purity:99.54%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor (IC50 = 0.62 μM) that alters m6A levels on mRNA, promotes differentiation and induces apoptosis, with antitumor activity.ALKBH5 is an N6-methyladenosine (m6A) demethylase that is closely related to leukemogenesis.
Chemical Properties
Molecular Weight231.25
FormulaC13H13NO3
Cas No.140481-05-6
SmilesO=C1C=CC(=O)N1CCC=2C=CC=CC2OC
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

ALKBH5IN5
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