REG3B Protein, Mouse, Recombinant (His)

Name: REG3B Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPY-03673
Rating: 4.5 (1 reviews)

(Synonyms: REG-III, PAP1, Pap, HIP) Copy Product Info

Synonyms: REG-III, PAP1, Pap, HIP

Catalog No. TMPY-03673 Copy Product Info

Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its expression level in colorectal tumors correlated inversely with pSTAT3 level and survival times of patients. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis.

Pack Size	Price	USA Stock	Global Stock
5 μg	$93	7-10 days	7-10 days
10 μg	$152	7-10 days	7-10 days
20 μg	$248	7-10 days	7-10 days
50 μg	$577	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity


Description	Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its expression level in colorectal tumors correlated inversely with pSTAT3 level and survival times of patients. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P35230
Construction	A DNA sequence encoding the mouse REG3B (NP_035166.1) (Met1-Gly175) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Glu 27
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Synonyms	REG-III, PAP1, Pap, HIP
Research Background

Chemical Properties

Molecular Weight

49.2 kDa (predicted); 19 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Storage

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PAP-1PAP 1

Related Tags: REG3B Protein, Mouse, Recombinant (His) chemical structure | REG3B Protein, Mouse, Recombinant (His) molecular weight