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Halcinonide

Name: Halcinonide
Brand: TargetMol
SKU: T0107
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SQ-18566, Halcinonida, Halcimat, Halciderm) Copy Product Info

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Synonyms: SQ-18566, Halcinonida, Halcimat, Halciderm

Catalog No. T0107 Copy Product Info

Purity: 99.93%

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Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.

Cas No. 3093-35-4

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Pack Size	Price	USA Stock	Global Stock
10 mg	$40	In Stock	In Stock
25 mg	$59	In Stock	In Stock
50 mg	$74	In Stock	In Stock
100 mg	$133	In Stock	In Stock
200 mg	$215	In Stock	In Stock
500 mg	$392	In Stock	In Stock
1 g	$597	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.93%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.
In vitro	After administering 0.1% Halcinonide cream for three days, the total number of peritoneal white blood cells in rats decreased from 270 million to 120.73 million. The same dosage of the drug, when applied to the surface of injured rat cecum for 3 and 7 days, significantly reduced the average adhesion scores, with the adhesion rates in the experimental and control groups being 43.3% and 100%, respectively.
In vivo	Halcinonide interacts with hormone receptors in the cytoplasm, eliciting anti-inflammatory effects. It is employed in the treatment of certain skin disorders.
Synonyms	SQ-18566, Halcinonida, Halcimat, Halciderm

Chemical Properties

Molecular Weight	454.96
Formula	C₂₄H₃₂ClFO₅
Cas No.	3093-35-4
Smiles	CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CCl
Relative Density.	1.31 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (554.99 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 4 mg/mL (8.79 mM), Heating is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.52 mg/mL (5.54 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1980 mL	10.9900 mL	21.9800 mL	109.8998 mL
5 mM	0.4396 mL	2.1980 mL	4.3960 mL	21.9800 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2198 mL	1.0990 mL	2.1980 mL	10.9900 mL
20 mM	0.1099 mL	0.5495 mL	1.0990 mL	5.4950 mL
50 mM	0.0440 mL	0.2198 mL	0.4396 mL	2.1980 mL
100 mM	0.0220 mL	0.1099 mL	0.2198 mL	1.0990 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc