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Levomepromazine

Name: Levomepromazine
Brand: TargetMol
SKU: T15743
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15743Cas No. 60-99-1

Alias Methotrimeprazine

Levomepromazine (Methotrimeprazine) is an orally active aliphatic phenothiazine antipsychotic compound and a Ca2+ release inducer, exhibiting antiviral, anti-inflammatory, neuroprotective, analgesic, and anti-nociceptive activities. Levomepromazine inhibits dopaminergic, cholinergic, serotoninergic, and histaminergic receptors, and is used for research in neurodegenerative diseases.

Levomepromazine

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Purity: 99.15%

Catalog No. T15743Alias MethotrimeprazineCas No. 60-99-1

Pack Size	Price	Availability	Quantity
2 mg	$30	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock

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Purity:99.15%

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Product Introduction

Bioactivity

Description	Levomepromazine (Methotrimeprazine) is an orally active aliphatic phenothiazine antipsychotic compound and a Ca2+ release inducer, exhibiting antiviral, anti-inflammatory, neuroprotective, analgesic, and anti-nociceptive activities. Levomepromazine inhibits dopaminergic, cholinergic, serotoninergic, and histaminergic receptors, and is used for research in neurodegenerative diseases.
In vitro	Levomepromazine(0.01-200 μM,72h) increased the CYP3A4 activity of HU1832 to 152% at 2.5 μM. [1] Levomepromazine (10 μM, 24 h) reduced Japanese encephalitis virus (JEV) -induced Neuro2a cell death, decreased JEV RNA levels and viral titers, and significantly inhibited JEV protein translation/replication complex formation and ROS production. Levomepromazine (10 μM, 24 h) reduces inflammation in microglia by inducing autophagy. [2]
In vivo	Levomepromazine (5-20 mg/kg; Intraperitoneal injection) has analgesic, sedative and anti-injurious effects in mice [4].
Synonyms	Methotrimeprazine

Chemical Properties

Molecular Weight	328.47
Formula	C₁₉H₂₄N₂OS
Cas No.	60-99-1
Smiles	C([C@@H](CN(C)C)C)N1C=2C(SC=3C1=CC=CC3)=CC=C(OC)C2
Relative Density.	1.0897 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (91.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0444 mL	15.2221 mL	30.4442 mL	152.2209 mL
5 mM	0.6089 mL	3.0444 mL	6.0888 mL	30.4442 mL
10 mM	0.3044 mL	1.5222 mL	3.0444 mL	15.2221 mL
20 mM	0.1522 mL	0.7611 mL	1.5222 mL	7.6110 mL
50 mM	0.0609 mL	0.3044 mL	0.6089 mL	3.0444 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc