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Anti-DLL4 Antibody (9U391)

😃Good
Catalog No. TMAY-00399
Alias δ-like 4 (Drosophila), δ-like 4, hδ2, hdelta2, delta-like 4 (Drosophila), Delta-like 4

Anti-DLL4 Antibody (9U391) is a Mouse antibody targeting DLL4. Anti-DLL4 Antibody (9U391) can be used in ELISA.

Anti-DLL4 Antibody (9U391)

Anti-DLL4 Antibody (9U391)

😃Good
Catalog No. TMAY-00399Alias δ-like 4 (Drosophila), δ-like 4, hδ2, hdelta2, delta-like 4 (Drosophila), Delta-like 4
Anti-DLL4 Antibody (9U391) is a Mouse antibody targeting DLL4. Anti-DLL4 Antibody (9U391) can be used in ELISA.
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100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-DLL4 Antibody (9U391) is a Mouse antibody targeting DLL4. Anti-DLL4 Antibody (9U391) can be used in ELISA.
Aliasδ-like 4 (Drosophila), δ-like 4, hδ2, hdelta2, delta-like 4 (Drosophila), Delta-like 4
Ig Type
Monoclonal Mouse IgG2a
Clone
9U391
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human DLL4 / Delta-like 4 (rh DLL4; TMPY-01321; NP_061947.1; Met1-Pro524).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundDelta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent studies yield substantial insights into the role of DLL4 in angiogenesis. DLL4 is induced by vascular endothelial growth factor (VEGF) and acts downstream of VEGF as a 'brake' on VEGF-induced vessel growth, forming an autoregulatory negative feedback loop inactivating VEGF. DLL4 is downstream of VEGF signaling and its activation triggers a negative feedback that restrains the effects of VEGF. Attenuation of DLL4/Notch signaling results in chaotic vascular network with excessive branching and sprouting. DLL4 is widely distributed in tissues other than vessels including many malignancies. Furthermore, the molecule is internalized on binding its receptor and often transported to the nucleus. In pathological conditions, such as cancer, DLL4 is up-regulated strongly in the tumour vasculature. Blockade of DLL4-mediated Notch signaling strikingly increases nonproductive angiogenesis, but significantly inhibits tumor growth in preclinical mouse models. In preclinical studies, blocking of DLL4/Notch signaling is associated with a paradoxical increase in tumor vessel density, yet causes marked growth inhibition due to functionally defective vasculature. Thus, DLL4 blockade holds promise as an additional strategy for angiogenesis-based cancer therapy.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human DLL4 / Delta-like 4 protein (TMPY-01321)
Antigen Species
Human
Biology Area
Cancer Drug Targets, Notch Pathway
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

Sci Citations

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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