GDNF Protein, Human, Recombinant

Catalog No. TMPY-06970 Copy Product Info

GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.

GDNF Protein, Human, Recombinant

Catalog No. TMPY-06970

Copy Product Info

GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.

Pack Size	Price	USA Stock	Global Stock
5 μg	$124	-	In Stock
10 μg	$186	-	In Stock
20 μg	$279	In Stock	In Stock
50 μg	$570	7-10 days	7-10 days
100 μg	$983	-	In Stock

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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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COA User Guide of Recombinant Proteins

Product Information

Biological Activity	Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED50 for this effect is typically 1-5 ng/mL in the presence of Recombinant Human GFR alpha‑1/GDNF R alpha‑1 His Chimera.
Description	GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P39905-1
Synonyms	HSCR3,HFB1-GDNF,glial cell derived neurotrophic factor,ATF2,ATF1
Construction	A DNA sequence encoding the Human GDNF (P39905-1) (Ser78-Ile211) was expressed. Predicted N terminal: Met
Protein Purity	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
Molecular Weight	15.2 kDa (predicted)
Endotoxin	< 10 EU/mg of the protein.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 30% acetonitrile, 1/1000 TFA. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with 4 mM HCl to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). It has been found that GFLs play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. As the founding member, GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. It has been shown that GDNF results in two Parkinson's disease clinical trial and in a number of animal trials. It has been taken as a potent survival factor for central motoneurons.