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CDK12-IN-2

Name: CDK12-IN-2
Brand: TargetMol
SKU: T39752
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39752Cas No. 2244987-03-7

Alias CDK12-IN-2, CDK12 inhibitor 2

CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.

CDK12-IN-2

🥰Excellent

Purity: 99.31%

Catalog No. T39752Alias CDK12-IN-2, CDK12 inhibitor 2Cas No. 2244987-03-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$93	-	In Stock
5 mg	$228	-	In Stock
10 mg	$396	-	In Stock
25 mg	$653	-	In Stock
50 mg	$936	-	In Stock
100 mg	$1,260	-	In Stock
1 mL x 10 mM (in DMSO)	$268	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.31%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.
Targets&IC50	CDK2:>100 μM (IC50), CDK7:>10 μM (IC50), CDK12:52 nM (IC50), CDK9:16 μM (IC50)
In vitro	In SK-BR-3 cells, CDK12-IN-2 inhibits the phosphorylation of the CTD Ser2 with an IC50 of 185 nM. CDK12-IN-2 exhibits a growth inhibition with an IC50 of 0.8 μM. CDK12-IN-2 inhibits CDK12 in a time dependent manner with IC50s of 0.0078 μM, 0.042 μM, 0.057 μM,and 0.059 μM, for 0h, 1h, 2h and 5h[1].
Synonyms	CDK12-IN-2, CDK12 inhibitor 2

Chemical Properties

Molecular Weight	532.64
Formula	C₃₂H₃₂N₆O₂
Cas No.	2244987-03-7
Smiles	Cn1cc(ccc1=O)-c1ccc(cc1)N([C@H]1CC[C@@H](CC1)Nc1ccc(cn1)C#N)C(=O)NCc1ccccc1
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (93.87 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (4.69 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8774 mL	9.3872 mL	18.7744 mL	93.8720 mL
5 mM	0.3755 mL	1.8774 mL	3.7549 mL	18.7744 mL
10 mM	0.1877 mL	0.9387 mL	1.8774 mL	9.3872 mL
20 mM	0.0939 mL	0.4694 mL	0.9387 mL	4.6936 mL
50 mM	0.0375 mL	0.1877 mL	0.3755 mL	1.8774 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc