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2'-Deoxyadenosine

Name: 2'-Deoxyadenosine
Brand: TargetMol
SKU: T20041
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20041Cas No. 958-09-8

Alias NSC-141848, NSC141848, NSC 141848

2'-Deoxyadenosine (NSC-141848) is the DNA nucleoside A. It pairs with deoxythymidine (T) in double-stranded DNA.

2'-Deoxyadenosine

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Purity: 99.71%

Catalog No. T20041Alias NSC-141848, NSC141848, NSC 141848Cas No. 958-09-8

2'-Deoxyadenosine (NSC-141848) is the DNA nucleoside A. It pairs with deoxythymidine (T) in double-stranded DNA.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$39	In Stock	In Stock
500 mg	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.71%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

2'-Deoxyadenosine AI Summary

2'-Deoxyadenosine exhibits a broad spectrum of bioactivities and kinetic behaviors. It shows bioactivity related to deamination by adenosine deaminase with a Km value of 31000 nM and a Vmax of 353.0 μM min-1 (mg of protein)-1, indicating moderate deamination rates. The compound acts as an effective inhibitor of S49 mouse lymphoma T-cells with an IC50 value of 180000 nM, which is enhanced to 30 nM in the presence of EHNA. It also inhibits adenylate cyclase from rat brain with an IC50 value of 15000 nM. In terms of antiviral properties, 2'-Deoxyadenosine has a MIC greater than 100.0 μg/mL for most viruses but shows a lower MIC of 20.0 μg/mL against Respiratory syncytial virus. It exhibits weak or no inhibitory activity against HSV1 thymidine kinase with an IC50 value greater than 1000.0 μM. Its partition coefficient in 1-octanol and aqueous buffer (pH 7.4) is P = 0.283. The compound shows affinity for adenosine receptors with a Ki value of 23300 nM for the Adenosine A1 receptor in the presence of GTP and notable displacement percentages for adenosine A1, A2A, and A3 receptors. It does, however, demonstrate low inhibitory concentrations against specific viruses in various cell cultures, and moderate affinity towards the adenine 1 receptor in rat brain cortical membrane (Ki = 11000 nM). For deoxycytidine kinase, 2'-Deoxyadenosine exhibits activity with variations in Kcat and Km values under conditions involving ATP and UTP. Against woodchuck hepatitis virus, it provides a log reduction in serum viral DNA after 4 weeks. The compound also shows moderate inhibition of Staphylococcus aureus deoxyadenosine kinase (Km = 29200 nM, Vmax = 4.1 U/mg). Other notable activities include inhibition of [3H]adenosine uptake by Trypanosoma brucei brucei 427 P2 transporter (Ki = 230 nM), 13.0% inhibition against penicillin-resistant Streptococcus pneumoniae 159 recombinant MurM at 1 mM, and inhibition of viral DNA replication in duck hepatocytes and HBV in human cells at concentrations of 10 μg/mL. Additionally, 2'-Deoxyadenosine inhibits the growth of Trichomonas vaginalis T1 with 48.7% growth inhibition at 100 μM, and shows inhibition percentages in sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at 10 μM (106.41% and 112.32% respectively). The compound demonstrates low cytotoxicity with an IC50 value greater than 250000 nM across various cell lines. Moreover, it acts as a modulator of adenosine receptors, showing varying inhibition across A1 (5.0%), A2A (2.0%), A2B (12.0%), and A3 (5.0%) receptors, and demonstrates involvement in drug metabolism with a rate constant of 0.96 L/mol/min..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2'-Deoxyadenosine (NSC-141848) is the DNA nucleoside A. It pairs with deoxythymidine (T) in double-stranded DNA.
Synonyms	NSC-141848, NSC141848, NSC 141848

Chemical Properties

Molecular Weight	251.24
Formula	C₁₀H₁₃N₅O₃
Cas No.	958-09-8
Smiles	Nc1ncnc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1
Relative Density.	1.91g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.52 mg/mL (10.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9803 mL	19.9013 mL	39.8026 mL	199.0129 mL
5 mM	0.7961 mL	3.9803 mL	7.9605 mL	39.8026 mL
10 mM	0.3980 mL	1.9901 mL	3.9803 mL	19.9013 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc