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Anti-PD-1 Antibody (2U287)
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Catalog No. TMAH-00864
Alias SLEB2, PDCD1, PD-1, PD1, CD279
Anti-PD-1 Antibody (2U287) is an antibody targeting PD-1. Anti-PD-1 Antibody (2U287) can be used in ELISA.
Anti-PD-1 Antibody (2U287)
Anti-PD-1 Antibody (2U287)
😃Good
Catalog No. TMAH-00864Alias SLEB2, PDCD1, PD-1, PD1, CD279
Anti-PD-1 Antibody (2U287) is an antibody targeting PD-1. Anti-PD-1 Antibody (2U287) can be used in ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $209 | 7-10 days | 7-10 days | |
| 100 μL | $348 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PD-1 Antibody (2U287) is an antibody targeting PD-1. Anti-PD-1 Antibody (2U287) can be used in ELISA. |
| Synonyms | SLEB2, PDCD1, PD-1, PD1, CD279 |
| Ig Type | Human IgG4 |
| Clone | 2U287 |
| Reactivity | Human |
| Verified Activity | The Binding Activity of PD-1 with anti-PD-1 antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human PD-1 at 2 μg/mL can bind Anti-PD-1 recombinant antibody, the EC50 is 1.960-3.961 ng/mL. |
| Application | |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human PD-1 Protein |
| Antigen Species | Human |
| Gene Name | PDCD1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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