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γ-Secretase-IN-1

Catalog No. T3521 CAS 209986-17-4

Synonyms: Compound E

γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

γ-Secretase-IN-1, CAS 209986-17-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 173.00
5 mg	In stock	$ 428.00
10 mg	In stock	$ 763.00
25 mg	In stock	$ 1,560.00
50 mg	In stock	$ 2,110.00
100 mg	In stock	$ 2,930.00

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Purity: 99.56%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.
Targets&IC50	β-amyloid(42):0.37 nM, Notch:0.24 nM, β-amyloid(40):0.24 nM
In vitro	At a concentration of 50 μM, compound E reduces the proliferation of T47D and MCF-7 cell lines by less than 50% [2].

Synonyms	Compound E
Molecular Weight	490.5
Formula	C27H24F2N4O3
CAS No.	209986-17-4

Storage

keep away from moisture,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (163.10 mM), Sonication is recommended.

References and Literature

1. Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100(12):1879-88. 2. Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library

Related Products

Related compounds with same targets

Methyl tridecanoate Hederacolchiside E Ezeprogind disulfate DSS30 CGP52411 β-Amyloid (1-15) 2-O-Acetyl-20-hydroxyecdysone Pinostrobin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

γ-Secretase-IN-1 209986-17-4 Neuroscience Proteases/Proteasome Stem Cells Gamma-secretase Beta Amyloid Compound E inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.