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γ-Secretase-IN-1

Name: γ-Secretase-IN-1
Brand: TargetMol
SKU: T3521
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3521Cas No. 209986-17-4

Alias Compound E

γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.

γ-Secretase-IN-1

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Purity: 99.56%

Catalog No. T3521Alias Compound ECas No. 209986-17-4

γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$129	In Stock	In Stock
5 mg	$428	In Stock	In Stock
10 mg	$687	In Stock	In Stock
25 mg	$1,360	In Stock	In Stock
50 mg	$1,830	In Stock	In Stock
100 mg	$2,480	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$463	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.
Targets&IC50	β-Amyloid (1–40):0.24 nM, Notch:0.24 nM, β-Amyloid (1–42):0.37 nM
In vitro	At a concentration of 50 μM, compound E reduces the proliferation of T47D and MCF-7 cell lines by less than 50% [2].
Synonyms	Compound E

Chemical Properties

Molecular Weight	490.5
Formula	C₂₇H₂₄F₂N₄O₃
Cas No.	209986-17-4
Smiles	C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O
Relative Density.	1.31 g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 165 mg/mL (336.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0387 mL	10.1937 mL	20.3874 mL	101.9368 mL
5 mM	0.4077 mL	2.0387 mL	4.0775 mL	20.3874 mL
10 mM	0.2039 mL	1.0194 mL	2.0387 mL	10.1937 mL
20 mM	0.1019 mL	0.5097 mL	1.0194 mL	5.0968 mL
50 mM	0.0408 mL	0.2039 mL	0.4077 mL	2.0387 mL
100 mM	0.0204 mL	0.1019 mL	0.2039 mL	1.0194 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc