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Betamethasone

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Catalog No. T1652Cas No. 378-44-9
Alias SCH-4831, NSC-39470

Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.

Betamethasone

Betamethasone

😃Good
Purity: 99.46%
Catalog No. T1652Alias SCH-4831, NSC-39470Cas No. 378-44-9
Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.
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1 mL x 10 mM (in DMSO)TBDBackorder
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Purity:99.46%
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Product Introduction

Bioactivity
Description
Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.
In vitro
Betamethasone has a specific affinity for type II glucocorticoid receptors which are present in most brain regions. [1]
In vivo
Betamethasone has direct vasoconstrictor effects on peripheral femoral resistance vessels in late gestation fetal sheep. Betamethasone exposure decreases cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 hours of infusion in sheep. [1] Betamethasone reduces the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induces the expression of IL-10 in the brain, all of which correlate with the changes of pain thresholds in rats. [2] Betamethasone exposure reduces synaptophysin-LI in the frontal neocortex, caudate putamen and hippocampus by 46.9%, 41.0% and 55.4%, respectively, that is not accompanied by irreversible neuronal damage in the fetal sheep brain. [3] Betamethasone modestly increases cytidylyltransferase (CT) mRNA, but does not alter the levels of immunoreactive enzyme in adult rat lung. Betamethasone decreases the activities of the sphingomyelin hydrolases: acid sphingomyelinase by 33% and of alkaline ceramidase by 21%. [4] Betamethasone injected at the time of nerve injury partially inhibits the development of neuropathic hyperalgesia and reduces the subsequent elevated levels of pro-inflammatory cytokines in the brain of rats, while stimulating the expression of the anti-inflammatory cytokine IL-10. [5]
AliasSCH-4831, NSC-39470
Chemical Properties
Molecular Weight392.46
FormulaC22H29FO5
Cas No.378-44-9
Smiles[C@@]12([C@H]([C@H]3[C@](C[C@@H]2O)([C@]([C@H](C3)C)(C(=O)CO)O)C)CCC2=CC(=O)C=C[C@]12C)F
Relative Density.0.305 g/cm3. Temperature:25 °C.;0.503 g/cm3. Temperature:25 °C.
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 73 mg/mL (186.01 mM), Sonication is recommended.
Ethanol: 10 mg/mL (25.48 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.5480 mL12.7402 mL25.4803 mL127.4015 mL
5 mM0.5096 mL2.5480 mL5.0961 mL25.4803 mL
10 mM0.2548 mL1.2740 mL2.5480 mL12.7402 mL
20 mM0.1274 mL0.6370 mL1.2740 mL6.3701 mL
DMSO
1mg5mg10mg50mg
50 mM0.0510 mL0.2548 mL0.5096 mL2.5480 mL
100 mM0.0255 mL0.1274 mL0.2548 mL1.2740 mL

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