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Olprinone

Name: Olprinone
Brand: TargetMol
SKU: T5033
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5033Cas No. 106730-54-5

Alias Loprinone

Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB).

Olprinone

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Purity: 99.68%

Catalog No. T5033Alias LoprinoneCas No. 106730-54-5

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$36	In Stock	In Stock
25 mg	$74	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$169	In Stock	In Stock
200 mg	$253	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Olprinone AI Summary

Olprinone exhibits a diverse range of bioactivities, being particularly notable for its antiviral and enzyme inhibitory properties. It acts as a potentiator of the human D1 dopamine receptor with a potency of 3264.1 nM and shows significant inhibition against Histone Lysine Methyltransferase G9a at 12589.3 nM. It demonstrates promising inhibitory activity against T. brucei phosphofructokinase with a potency of 756.9 nM and inhibits HP1-beta Chromodomain interactions at 5011.9 nM. In human embryonic kidney cells, Olprinone inhibits ELG1-dependent DNA repair with a potency of 18348.9 nM and exhibits dual inhibitory activity on ATXN expression with potencies of 8912.5 nM and 3162.3 nM. Furthermore, this compound inhibits the Regulator of G Protein Signaling 4 at 37685.8 nM and has demonstrated potent inhibition of Marburg virus entry into cells (446.7 nM) and Lassa virus (32.6 nM). Additionally, it shows activity against HBL1 and TMD8 cell lines with potencies of 13206.6 nM and 2956.6 nM respectively and inhibits Plasmodium falciparum proliferation at potencies ranging from 0.7 nM to 16774.4 nM. In an immunotoxin study, it shows sensitization effects with a potency of 7426.6 nM. Olprinone also possesses antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells, though the activity is relatively low with a hit score of 0.1194. It exhibits selective inhibition of human HDAC6, reducing enzymatic activity by -26.79% with a commercial peptide substrate. While generally displaying high AC50 values (>30,000.0 nM) in binding affinity towards various human receptors and enzymes, it effectively inhibits human PDE3A (AC50 = 707.6 nM) and PDE4A (AC50 = 5185.5 nM) in cell-free assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB).
Targets&IC50	PDE3:0.35 μM (IC50), PDE2:100 μM (IC50), PDE1:150 μM (IC50), PDE4:14 μM (IC50)
Synonyms	Loprinone

Chemical Properties

Molecular Weight	250.26
Formula	C₁₄H₁₀N₄O
Cas No.	106730-54-5
Smiles	Cc1[nH]c(=O)c(cc1-c1ccc2nccn2c1)C#N
Relative Density.	1.34g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.51 mg/mL (10.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9958 mL	19.9792 mL	39.9584 mL	199.7922 mL
5 mM	0.7992 mL	3.9958 mL	7.9917 mL	39.9584 mL
10 mM	0.3996 mL	1.9979 mL	3.9958 mL	19.9792 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc