Shopping Cart

Your shopping cart is currently empty

Moxalactam Disodium

Name: Moxalactam Disodium
Brand: TargetMol
SKU: T6179
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T6179Cas No. 64953-12-4

Alias Shiomarin, S 6059, LY-127935, Latamoxef sodium, FestamoxinLy, Antibiotic 6059S, 6059 S

Moxalactam sodium salt (LY-127935) is an antibiotic compound more effective against Escherichia coli and Pseudomonas aeruginosathan cephalosporins.

Moxalactam Disodium

Copy Product Info

😃Good

Catalog No. T6179Alias Shiomarin, S 6059, LY-127935, Latamoxef sodium, FestamoxinLy, Antibiotic 6059S, 6059 SCas No. 64953-12-4

Moxalactam sodium salt (LY-127935) is an antibiotic compound more effective against Escherichia coli and Pseudomonas aeruginosathan cephalosporins.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS

Product Introduction

Moxalactam Disodium AI Summary

Moxalactam Disodium exhibits diverse pharmacological activities and significant bioactivities. Pharmacokinetically, it shows varying volumes of distribution and clearance rates across different species. In humans, the volume of distribution is 0.27 L·kg^-1, and the clearance is 1.2 mL·min^-1·kg^-1, while it presents different profiles in animal models like monkeys, dogs, and rats. Evaluated for hepatotoxicity, Moxalactam Disodium demonstrates moderate liver toxicity, involving various types of liver damage and hepatocellular responses. However, in the Drug Induced Liver Injury Prediction System (DILIps) validation dataset, it is classified as DILI negative, indicating no toxic effects on the liver per Pfizer's assay. Antibacterial properties of Moxalactam Disodium are significant, showing broad-spectrum activity against both Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains. Particularly, it exhibits a MIC of 0.12 µg/mL against wild type Escherichia coli expressing the AcrAB-TolC efflux pump. However, its activity against Pseudomonas aeruginosa requires higher MICs. Additionally, it exhibits considerable inhibition of OATP1B1 and OATP1B3 transfected CHO cells, with 87.94% and 92.91% inhibition at 10 µM, respectively. Antiviral activities are notable as well, wherein Moxalactam Disodium effectively blocks Ebola virus entry with AC50 values of 0.631 µM and 631.0 nM in different assays. It also inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells by 5.09% at 10 µM after 48 hours and shows 10.38% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. Nevertheless, its impact on VERO-6 cells' cytotoxicity induced by SARS-CoV-2 was marginal, with a -0.04% inhibition at 10 µM after 48 hours. Overall, Moxalactam Disodium demonstrates multifaceted pharmacological potential spanning antibacterial, antiviral, and pharmacokinetic profiles..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Moxalactam sodium salt (LY-127935) is an antibiotic compound more effective against Escherichia coli and Pseudomonas aeruginosathan cephalosporins.
Synonyms	Shiomarin, S 6059, LY-127935, Latamoxef sodium, FestamoxinLy, Antibiotic 6059S, 6059 S

Chemical Properties

Molecular Weight	564.44
Formula	C₂₀H₁₈N₆Na₂O₉S
Cas No.	64953-12-4
Smiles	[Na+].[Na+].CO[C@]1(NC(=O)C(C([O-])=O)c2ccc(O)cc2)[C@H]2OCC(CSc3nnnn3C)=C(N2C1=O)C([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (106.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7717 mL	8.8583 mL	17.7167 mL	88.5834 mL
5 mM	0.3543 mL	1.7717 mL	3.5433 mL	17.7167 mL
10 mM	0.1772 mL	0.8858 mL	1.7717 mL	8.8583 mL
20 mM	0.0886 mL	0.4429 mL	0.8858 mL	4.4292 mL
50 mM	0.0354 mL	0.1772 mL	0.3543 mL	1.7717 mL
100 mM	0.0177 mL	0.0886 mL	0.1772 mL	0.8858 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc