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Enoblituzumab is a humanized IgG1 κmab monoclonal antibody that recognizes human B7-H3 protein and can be used to study solid tumors such as non-small cell lung cancer (NSCLC).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 483.00 | |
10 mg | In stock | $ 692.00 | |
25 mg | In stock | $ 1,080.00 | |
50 mg | In stock | $ 1,490.00 | |
100 mg | In stock | $ 2,100.00 |
Description | Enoblituzumab is a humanized IgG1 κmab monoclonal antibody that recognizes human B7-H3 protein and can be used to study solid tumors such as non-small cell lung cancer (NSCLC). |
In vitro | Enoblituzumab interacts with B7-H3, resulting in potent antibody-dependent cellular cytotoxicity (ADCC) across a broad range of cancer cells[2]. It effectively mediates ADCC against A498 cells at concentrations ranging from 0.01 ng/mL to 10 mg/mL using cynomolgus monkey peripheral blood mononuclear cells (PBMCs)[3]. |
In vivo |
In mice (mCD16-/-hCD16A+) with murine CD16 gene knocked out and transgenic for human CD16A-158F, enoblituzumab (5 mg/kg; i.v.; single dose) exhibits an estimated half-life of 249 hours with a Cmax of 43 mg/mL[3]. Exhibiting potent antitumor activity in xenograft mice models of renal cell and bladder carcinoma expressing B7-H3, enoblituzumab (0.1-10 mg/kg; i.v.; once weekly; 5 weeks) shows this effect[3]. |
Synonyms | MGA271, TJ-271 |
Molecular Weight | N/A |
CAS No. | 1353485-38-7 |
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Enoblituzumab 1353485-38-7 Others TJ271 MGA271 TJ-271 TJ 271 MGA-271 MGA 271 inhibitor inhibit