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Anti-CD3D Antibody (2U54)
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Catalog No. TMAH-00194
Anti-CD3D Antibody (2U54) is an antibody targeting CD3D. Anti-CD3D Antibody (2U54) can be used in ELISA, WB.
Anti-CD3D Antibody (2U54)
Anti-CD3D Antibody (2U54)
😃Good
Catalog No. TMAH-00194
Anti-CD3D Antibody (2U54) is an antibody targeting CD3D. Anti-CD3D Antibody (2U54) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, WB Reactivity: Human |
| Ig Type | hIgG1 |
| Clone | 2U54 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: Jurkat whole cell lysate -All lanes: CD3D antibody at 1:1000 -Secondary: Goat polyclonal to human IgG at 1/50000 dilution -Predicted band size: 19 kDa -Observed band size: 19 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:2000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456). |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CD3D Protein |
| Antigen Species | Human |
| Gene ID | 915 |
| Uniprot ID | |
| Biology Area | Immunology, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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