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Temoporfin
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Catalog No. T17035Cas No. 122341-38-2
Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck.
Temoporfin
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Purity: 99.71%
Catalog No. T17035Cas No. 122341-38-2
Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $45 | In Stock | In Stock | |
| 2 mg | $64 | In Stock | In Stock | |
| 5 mg | $107 | In Stock | In Stock | |
| 10 mg | $187 | In Stock | In Stock | |
| 25 mg | $383 | In Stock | In Stock | |
| 50 mg | $569 | In Stock | In Stock | |
| 100 mg | $817 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $162 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.71%
Appearance:Solid
Color:Black
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Product Introduction
Temoporfin AI Summary
Temoporfin demonstrates various bioactivities and physicochemical properties. It has a drug level ratio of 3.0 in tumor to skin in iv dosed BDXI rats implanted with rat LSBD1 cells after 24 hours. The compound is soluble in 25% aqueous ethanolic medium at 25°C with a solubility of 600000.0 nM. It exhibits significant antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 cells by 85.92% at 10 µM, and has a 30.74% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. In VERO-6 cells, it shows a 2.08% inhibition rate at 10 µM after 48 hours against SARS-CoV-2.
Additionally, Temoporfin has photodynamic antibacterial activity against Enterococcus faecalis at 10 µM and 30 µM concentrations under light irradiation, with log(activity) values of 5.8 and 6.7, respectively. It displays both photodynamic cytotoxicity and dark toxicity against human A549 cells and Enterococcus faecalis. In human QBC939 cells, it shows dark toxicity with a TC50 of 6.08 µM and phototoxic effects upon 650 nm laser irradiation in QBC939 cell xenografts in mice, reducing tumor weight by 35%.
The compound also demonstrates phototoxic effects against human HT-29 cells, human MDA-MB-231, mouse 4T1, and HUVEC cells, with varying IC50 values. It is a potent HDAC6 inhibitor, with inhibition percentages of 36.91% and 2.63% using different substrates. Moreover, it shows antiviral activity against West Nile virus, Zika virus, and DENV2, with EC50 values of 10.0 nM, 22.0 nM, and 20.0 nM, respectively. Additionally, it exhibits cytotoxicity against human A549 cells with a CC50 of 40700.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck. |
| Molecular Weight | 680.75 |
| Formula | C44H32N4O4 |
| Cas No. | 122341-38-2 |
| Smiles | Oc1cccc(c1)-c1c2CCc(n2)c(-c2cccc(O)c2)c2ccc([nH]2)c(-c2cccc(O)c2)c2ccc(n2)c(-c2cccc(O)c2)c2ccc1[nH]2 |
| Relative Density. | 1.386 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 27 mg/mL (39.66 mM), Sonication is recommended. | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.47 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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