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GP531

Name: GP531
Brand: TargetMol
SKU: T13713
Rating: 4.5 (1 reviews)

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Catalog No. T13713Cas No. 142344-87-4

GP531 is a second-generation adenosine regulating agent. It is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia.

GP531

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Catalog No. T13713Cas No. 142344-87-4

GP531 is a second-generation adenosine regulating agent. It is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

GP531 is a second-generation adenosine regulating agent. It is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia.

In vivo

GP531 administration does not alter heart rate or mean aortic pressure but significantly improves left ventricular function by reducing end-diastolic pressure, volumes, and wall stress, while enhancing ejection fraction (EF), deceleration time of early mitral inflow velocity, and the slope of end-systolic pressure-volume relationship (PVR), without an increase in myocardial oxygen consumption (MVO2). At low doses, GP531 diminishes infarct size by 34% and the no-reflow zone extent by 31% compared to control, with high doses achieving reductions of 22% and 16%, respectively. Unlike adenosine, GP531 does not impact overall hemodynamics or blood flow, showcasing its efficacy in mitigating ischemic/reperfusion injury severity at lower doses without inducing adverse hemodynamic events such as bradycardia and hypotension.

Chemical Properties

Molecular Weight	347.37
Formula	C₁₆H₂₁N₅O₄
Cas No.	142344-87-4
Smiles	NC(=O)c1ncn([C@@H]2O[C@H](CNCc3ccccc3)[C@@H](O)[C@H]2O)c1N
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (359.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8788 mL	14.3939 mL	28.7877 mL	143.9387 mL
5 mM	0.5758 mL	2.8788 mL	5.7575 mL	28.7877 mL
10 mM	0.2879 mL	1.4394 mL	2.8788 mL	14.3939 mL
20 mM	0.1439 mL	0.7197 mL	1.4394 mL	7.1969 mL
50 mM	0.0576 mL	0.2879 mL	0.5758 mL	2.8788 mL
100 mM	0.0288 mL	0.1439 mL	0.2879 mL	1.4394 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc