TGF-8027

Name: TGF-8027
Brand: TargetMol
SKU: T213714
Rating: 4.5 (1 reviews)

Catalog No. T213714 Copy Product Info

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TGF-8027 is a selective 5-HT2A receptor agonist capable of crossing the blood-brain barrier. It exhibits EC50 values of 3.3 nM for 5-HT2A, 160 nM for 5-HT2C, and 7600 nM for 5-HT2B receptors. In mice, TGF-8027 has an EC50 of 14 nM for 5-HT2A and 210 nM for 5-HT2C receptors. It can induce head-twitch responses in mice and is useful for researching diseases targeting the 5-HT2A receptor, such as depression.

TGF-8027

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Catalog No. T213714

TGF-8027

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	TGF-8027 is a selective 5-HT2A receptor agonist capable of crossing the blood-brain barrier. It exhibits EC50 values of 3.3 nM for 5-HT2A, 160 nM for 5-HT2C, and 7600 nM for 5-HT2B receptors. In mice, TGF-8027 has an EC50 of 14 nM for 5-HT2A and 210 nM for 5-HT2C receptors. It can induce head-twitch responses in mice and is useful for researching diseases targeting the 5-HT2A receptor, such as depression.
Targets&IC50	5-HT2A receptor:3.3 nM (EC50)
In vivo	TGF-8027 (administered as a single subcutaneous dose ranging from 0.4 to 40 mg/kg) induces head-twitch responses in mice in a dose-dependent manner, with an EC50 of 1.86 mg/kg.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc